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. 1991 Dec;65(12):7020–7024. doi: 10.1128/jvi.65.12.7020-7024.1991

Tumor immunity generated in the course of regression of v-src-induced sarcomas.

T W Wisner 1, J M England 1, D Y Pan 1, A W Stoker 1, M S Halpern 1
PMCID: PMC250820  PMID: 1658394

Abstract

Previous studies have indicated that the regression versus progression of v-src-DNA-induced sarcomas is dependent on chicken line. As a first step in analyzing the role of tumor immunity as a determinant of this line dependence, experiments were undertaken to ascertain whether an antisarcoma immune response is generated in the course of sarcoma growth in TK chickens, a regressor line. To assay for this response, test TK chickens in which v-src-induced wing web sarcomas had regressed, as well as control TK chickens that had not been exposed to v-src, were challenged in protocols known to yield v-src-dependent sarcoma formation and monitored for challenge sarcoma growth. Compared with the control chickens, the test chickens showed a significant resistance to the sarcomagenic challenge. These results raise the possibility that the antisarcoma response that is inducible in regressor lines, as demonstrated here in terms of a protective effect against a subsequent sarcomagenic challenge, may also underlie the regression of v-src-induced primary sarcomas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. England J. M., Panella M. J., Ewert D. L., Halpern M. S. Induction of a diffuse mesothelioma in chickens by intraperitoneal inoculation of v-src DNA. Virology. 1991 Jun;182(2):423–429. doi: 10.1016/0042-6822(91)90583-w. [DOI] [PubMed] [Google Scholar]
  2. Fung Y. K., Crittenden L. B., Fadly A. M., Kung H. J. Tumor induction by direct injection of cloned v-src DNA into chickens. Proc Natl Acad Sci U S A. 1983 Jan;80(2):353–357. doi: 10.1073/pnas.80.2.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Halpern M. S., England J. M., Coates L., Stoltzfus C. M., Mason W. S. Regression of v-src DNA-induced sarcomas is under host genetic control. Virology. 1991 Feb;180(2):857–860. doi: 10.1016/0042-6822(91)90107-m. [DOI] [PubMed] [Google Scholar]
  4. Halpern M. S., Ewert D. L., England J. M. Wing web or intravenous inoculation of chickens with v-src DNA induces visceral sarcomas. Virology. 1990 Mar;175(1):328–331. doi: 10.1016/0042-6822(90)90217-f. [DOI] [PubMed] [Google Scholar]
  5. Halpern M. S., McMahon S. B. The immune status of avian sarcoma virus-infected chickens as a determinant of sarcoma growth pattern and viral antigen expression. J Immunol. 1987 May 1;138(9):3014–3018. [PubMed] [Google Scholar]
  6. Phillips E. R., Ruch R. J. A nonviral, virus strain-specific antigen expressed on rat cells transformed by avian sarcoma virus. Cancer Res. 1986 Nov;46(11):5864–5868. [PubMed] [Google Scholar]
  7. Plachý J., Karakoz I., Benda V. Concomitant immunity leads to retardation or acceleration of the growth of Rous sarcomas in genetically resistant or susceptible inbred lines of chickens. Folia Biol (Praha) 1986;32(5):334–348. [PubMed] [Google Scholar]
  8. Stoker A. W., Sieweke M. H. v-src induces clonal sarcomas and rapid metastasis following transduction with a replication-defective retrovirus. Proc Natl Acad Sci U S A. 1989 Dec;86(24):10123–10127. doi: 10.1073/pnas.86.24.10123. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Stoltzfus C. M., Chang L. J., Cripe T. P., Turek L. P. Efficient transformation by Prague A Rous sarcoma virus plasmid DNA requires the presence of cis-acting regions within the gag gene. J Virol. 1987 Nov;61(11):3401–3409. doi: 10.1128/jvi.61.11.3401-3409.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Suda T., Shimizu J., Mizushima Y., Fujiwara H., Hamaoka T. Separation of the tumor rejection antigen of Rous sarcoma virus-induced murine fibrosarcoma. Jpn J Cancer Res. 1988 Mar;79(3):365–374. doi: 10.1111/j.1349-7006.1988.tb01600.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Suda T., Shimizu J., Muramatsu M., Kimura K., Yoshida T. O., Fukami Y., Fujiwara H., Hamaoka T. The tumor rejection antigen separated from Rous sarcoma virus-induced murine fibrosarcoma exhibits a molecular weight of approximately 60 kD but differs from functional pp60src. Jpn J Cancer Res. 1989 Sep;80(9):879–886. doi: 10.1111/j.1349-7006.1989.tb01730.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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