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. 1989 Jul;63(7):3109–3116. doi: 10.1128/jvi.63.7.3109-3116.1989

The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle.

C M Rooney 1, D T Rowe 1, T Ragot 1, P J Farrell 1
PMCID: PMC250868  PMID: 2542618

Abstract

A spliced cDNA spanning the Epstein-Barr virus BZLF1 gene expresses the BZLF1 protein and is active in inducing the virus productive cycle. A deletion mutant which lacks the N-terminal half of the protein is inactive. Cotransfection experiments in EBV-negative B-lymphocyte cell lines demonstrated that the BZLF1 gene activates the promoter for the BSLF2 + BMLF1 gene in the absence of any other EBV gene product. These results confirmed that the spliced BZLF1 gene is the transactivating gene structure in BamHI-Z.

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Selected References

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