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. 1989 Jul;63(7):3200–3204. doi: 10.1128/jvi.63.7.3200-3204.1989

Absence of mouse mammary tumor virus proviral amplification in chemically induced lymphomas of RF/J mice.

R Kraft 1, S T Ishizaka 1, S A Okenquist 1, G Childs 1, F Lilly 1, J Lenz 1
PMCID: PMC250883  PMID: 2542628

Abstract

RF/J mice are susceptible to the induction of thymic lymphomas by the carcinogens 3-methylcholanthrene and N-methyl-N-nitrosourea. Given the association of mouse mammary tumor virus (MMTV) with certain thymomas, we examined genomic DNA from chemically induced lymphomas of RF/J mice for new MMTV proviruses. Of 13 tissue culture lines derived from 3-methylcholanthrene-induced tumors, 5 had acquired new proviruses. MMTV amplification coincided with the appearance of viral mRNAs and proteins. However, no primary tumors or animal-passaged tumors contained new proviruses. These observations indicate that MMTV does not have a role in the tumor induction process, although it may become activated and amplified in tissue culture lines derived from tumors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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