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. 1989 Aug;63(8):3513–3515. doi: 10.1128/jvi.63.8.3513-3515.1989

Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system.

R A Harris 1, R D Everett 1, X X Zhu 1, S Silverstein 1, C M Preston 1
PMCID: PMC250929  PMID: 2545921

Abstract

Reactivation of latent herpes simplex virus type 2 (HSV-2) by the immediate-early protein Vmw110 was studied by using an in vitro latency system. Adenovirus recombinants that express Vmw110 reactivated latent HSV-2. An HSV-1 mutant possessing a deletion in a carboxy-terminal region of Vmw110 reactivated latent HSV-2, whereas mutant FXE, which has a deletion in the second exon, did not. Therefore, Vmw110 alone is required to reactivate latent HSV-2 in vitro, and the region of Vmw110 defined by the deletion in FXE is important for this process.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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