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. 1989 Oct;63(10):4434–4437. doi: 10.1128/jvi.63.10.4434-4437.1989

Splenic accumulation of interleukin-3-dependent hematopoietic cells in Friend erythroleukemia.

C Spiro 1, B C Gliniak 1, D Kabat 1
PMCID: PMC251064  PMID: 2789294

Abstract

Interleukin-3-dependent hematopoietic stem cells commonly accumulate in spleens of mice infected with leukemia viruses. To study their origins, a molecularly tagged helper-free Friend spleen focus-forming virus was used to produce erythroleukemias. Uninfected interleukin-3-dependent basophil-mast cell progenitors coproliferated amidst the spleen focus-forming virus-infected leukemic cells. Splenic proliferation of normal stem cells is apparently a host response to leukemogenesis, and we propose that it may contribute to certain retroviral diseases.

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Selected References

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