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. 1989 Nov;63(11):4945–4948. doi: 10.1128/jvi.63.11.4945-4948.1989

Differential DNA binding of nuclear proteins to a long terminal repeat region of the MCF13 and Akv murine leukemia viruses.

F K Yoshimura 1, J Tupper 1, K Diem 1
PMCID: PMC251142  PMID: 2552174

Abstract

Long terminal repeat (LTR) sequences of murine leukemia viruses (MLVs) have been demonstrated to be mainly responsible for the pathogenic differences in these retroviruses. A region of the LTR which is downstream of the enhancer elements has been shown to contribute both to enhancer activity as well as to disease specificity of MLVs. We have identified protein-DNA complexes generated by this region of a lymphomagenic MLV (MCF13) and one which is nonpathogenic (Akv). One protein-DNA complex we have observed for this region is unique to MCF13 DNA sequences. Detection of protein involved in this unique MCF13 complex in different cell lines revealed that it was ubiquitous.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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