Abstract
The infection of different Hfr strains of Escherichia coli bearing derepressed R factors of the fi+ or fi− type can result in the loss of the R factor and the conversion of the infected cells to the R− state. This extends earlier observations on the elimination of F′ factors by bacteriophage M13 infection. Variability in the efficiency of this conversion can arise because of genetic factors independent of the R factor being eliminated. A fraction of the infected but unconverted R+ cells were M13 carrier strains. The carrier state had an intracellular basis, and single R+ cells could maintain the carrier state.
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