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. 1972 Sep;111(3):745–749. doi: 10.1128/jb.111.3.745-749.1972

3′,5′-Cyclic Adenosine Monophosphate-Requiring Mutants of Escherichia coli1

Yoshinari Ohnishi a, Lorenzo Silengo a, Michihiko Kuwano a, David Schlessinger a
PMCID: PMC251348  PMID: 4340923

Abstract

Mutants that require exogenous 3′,5′-cyclic adenosine monophosphate (cAMP) for exponential growth were isolated from strains deficient in adenyl cyclase. Studies of one strain showed that cAMP is not incorporated into macromolecules; instead, it seems to have a regulatory function, i.e., in media lacking cAMP, cells form ribonucleic acid (RNA) and protein at linear rather than exponential rates. The exact lesion is not known; ribosomes, messenger RNA, and the β and β′ subunits of RNA polymerase continue to be made in absence of added cAMP.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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