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. 1972 Oct;112(1):84–92. doi: 10.1128/jb.112.1.84-92.1972

Multivalent Repression of Aspartic Semialdehyde Dehydrogenase in Escherichia coli K-12

Emmanuelle Boy 1, Jean-Claude Patte 1
PMCID: PMC251383  PMID: 4404058

Abstract

Mutants of Escherichia coli in which the lysine-sensitive aspartokinase is feedback-resistant are described. In these strains, as well as in the wild type, aspartic semialdehyde dehydrogenase is subject to multivalent repression by lysine, threonine, and methionine. When these amino acids were added to a culture in minimal medium, the differential rate of synthesis of the enzyme dropped to zero and remained there for about one generation.

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Selected References

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