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. 1972 Nov;112(2):761–772. doi: 10.1128/jb.112.2.761-772.1972

Genetic Studies on Plasmid-Linked Cadmium Resistance in Staphylococcus aureus

Katherine Smith a,1, Richard P Novick a
PMCID: PMC251484  PMID: 4343823

Abstract

The genetic basis of cadmium resistance conferred by three penicillinase plasmids, PI524, PI258, and PII147, of Staphylococcus aureus was examined by mutation, recombination, and deletion analysis. Three separate loci were identified: cadA, responsible for high-level resistance; cadB, giving a low-level resistance, nonadditive to cadA; and mad, a locus marginally decreasing the cadmium resistance of plasmid-positive staphylococci. The loci cadA and mad were present on all three plasmids, but cadB was only found on PII147. Spontaneous deletions of mad involved up to three-fourths of the plasmid genome, which allowed derivation of a partial deletion map of PII147, a plasmid with a contour length of 10.9 μm, corresponding to a molecular weight of 20.4 × 106.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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