Skip to main content
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1972 Nov;112(2):1020–1022. doi: 10.1128/jb.112.2.1020-1022.1972

Effect of Pyrrolnitrin on Electron Transport and Oxidative Phosphorylation in Mitochondria Isolated from Neurospora crassa

Alan M Lambowitz a,1, Carolyn W Slayman b
PMCID: PMC251518  PMID: 4343822

Abstract

Pyrrolnitrin, at low concentrations, uncouples oxidative phosphorylation in Neurospora mitochondria. At higher concentrations, pyrrolnitrin inhibits electron transport both in the flavine region and through cytochrome oxidase.

Full text

PDF
1020

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHANCE B., WILLIAMS G. R. The respiratory chain and oxidative phosphorylation. Adv Enzymol Relat Subj Biochem. 1956;17:65–134. doi: 10.1002/9780470122624.ch2. [DOI] [PubMed] [Google Scholar]
  2. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  3. Lambowitz A. M., Slayman C. W., Slayman C. L., Bonner W. D., Jr The electron transport components of wild type and poky strains of Neurospora crassa. J Biol Chem. 1972 Mar 10;247(5):1536–1545. [PubMed] [Google Scholar]
  4. Lambowitz A. M., Smith E. W., Slayman C. W. Electron transport in Neurospora mitochondria. Studies on wild type and poky. J Biol Chem. 1972 Aug 10;247(15):4850–4858. [PubMed] [Google Scholar]
  5. Lambowitz A. M., Smith E. W., Slayman C. W. Oxidative phosphorylation in Neurospora mitochondria. Studies on wild type, poky, and chloramphenicol-induced wild type. J Biol Chem. 1972 Aug 10;247(15):4859–4865. [PubMed] [Google Scholar]
  6. SLAYMAN C. W., TATUM E. L. POTASSIUM TRANSPORT IN NEUROSPORA. I. INTRACELLULAR SODIUM AND POTASSIUM CONCENTRATIONS, AND CATION REQUIREMENTS FOR GROWTH. Biochim Biophys Acta. 1964 Nov 29;88:578–592. [PubMed] [Google Scholar]
  7. Tripathi R. K., Gottlieb D. Mechanism of action of the antifungal antibiotic pyrrolnitrin. J Bacteriol. 1969 Oct;100(1):310–318. doi: 10.1128/jb.100.1.310-318.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Wong D. T., Airall J. M. The mode of action of antifungal agents: effect of pyrrolnitrin on mitochondrial electron transport. J Antibiot (Tokyo) 1970 Feb;23(2):55–62. doi: 10.7164/antibiotics.23.55. [DOI] [PubMed] [Google Scholar]
  9. Wong D. T., Horng J. S., Gordee R. S. Respiratory chain of a pathogenic fungus, Microsporum gypseum: effect of the antifungal agent pyrrolnitrin. J Bacteriol. 1971 Apr;106(1):168–173. doi: 10.1128/jb.106.1.168-173.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES