TABLE 1.
Distance (Mb)a | No. of alleles | Frequency of associated alleleb (no. of individuals)
|
Odds (C.I. of 95%)c | |||||
---|---|---|---|---|---|---|---|---|
Marker | Normal | PPD | χ2 (1)d | P-value | Pc valuee | |||
REN85M08 | 21.1 | 7 | 0/48 (24) | 17/42 (21) | — | 23.95 | 9.87 × 10−7 | 6.91 × 10−6 |
ShotR2 | 21.2 | 2 | 21/48 (24) | 41/44 (22) | 10.63 (2.51 45.06) | 16.24 | 5.58 × 10−5 | |
REN124F19 | 49.6 | 6 | 13/26 (23) | 17/42 (19) | 2.05 (0.81 5.18) | 2.46 | 0.12 | 0.72 |
Distances were based on the canine genome database (May 2005 for Boxer, http://genome.ucsc.edu).
Frequencies of highly associated alleles are presented as the number of a particular allele among the number of all alleles. In microsatellite analysis, P-values were obtained for all combinations, each with a particular allele versus the other alleles combined. Only the P-value for the most highly associated allele is shown. Individuals were selected from nine breeds (details in supplemental Table 3S).
C.I. denotes the confidence interval. The odds ratio for REN85M08 could not be estimated due to the lack of PPD-associated alleles in normal individuals.
χ2 values with degrees of freedom in parentheses were obtained using Pearson's method.
P-values were corrected by multiplying the number of microsatellite alleles observed for each locus.