TABLE 2.
Haplotype frequencyb
|
||||||
---|---|---|---|---|---|---|
Haplotypea | Normal | PPD | Odds ratio (C.I. of 95%)c | χ2 (1) | P-valued | Pc valuee |
1-CCCAGC | 0.250 | 0.727 | 8.00 (2.76 23.22) | 20.95 | 4.60 × 10−6 | 2.30 × 10−5 |
2-CCCAAC | 0.125 | 0.000 | 5.88 | 0.015 | 0.075 | |
3-TCCCAC | 0.312 | 0.068 | 6.21 (1.54 25.11) | 8.71 | 0.0032 | 0.016 |
4-TCCCGC | 0.250 | 0.137 | 2.11 (0.74 6.33) | 1.88 | 0.17 | |
5-CTTAGT | 0.063 | 0.068 | 1.09 (0.21 5.80) | 0.01 | 0.91 |
The SNPs used to construct haplotypes are Int16, Int15, Int6, ZRSi5, ShotR2, and Int3, whose positions on the canine genome are designated in supplemental Table 6S.
Individuals were selected from nine breeds, including 24 normal (10 homozygous and 14 heterozygous) and 22 PPD dogs (10 homozygous and 12 heterozygous).
C.I. denotes the confidence interval.
The P-values for the genotype level association with haplotype 1 are 6.27 × 10−6 (χ2 = 20.40) and 1.31 × 10−2 (χ2 = 6.15) for dominant and recessive modes of inheritance, respectively.
The P-values were corrected by multiplying the number of haplotypes.