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. Author manuscript; available in PMC: 2008 Aug 15.
Published in final edited form as: Biochemistry. 2006 Oct 17;45(41):12547–12559. doi: 10.1021/bi060857u

Table 4.

Specificity profilesa

Variant Energetic measures
CaM′ M13′ ΔΔGbind SpCaM′/M13 SpCaM/M13′ Spavg
F92W W4F +0.8 +2.2 −0.3 +1.0
F92W W4Y +1.0 +2.4* −0.5 +0.8
F92W, I125L W4F +0.6 +1.1 −0.6 −0.1
F92W, I125L
 W4Y
 +0.7
 +1.2*
 −0.8
 −0.3
S81R, E83K, E87R K19E +0.9 +0.3 −0.1 −0.8
S81R, E83N, E87H K19E +1.2* +0.8 +0.1 −0.3
S81R, E83H, E87H K19E +1.0* +0.1 −0.2 −1.1
a

Values in kcal/mol.

*

indicates data points with significance of p < 0.05 using the two-sample means test.