Figure 3.

Immunostaining of Cdc7 in primary breast and colon tumors. (A) Cdc7 protein staining of normal breast tissue (left) and the corresponding breast carcinoma (right) shown at low and high (below) magnifications. (B) Normal colon tissue (left) and tumor (right) stained for Cdc7 protein at low and high (below) magnifications. (C) Fluorescence in situ hybridization experiments were done as described in Figure 2. A representative picture of nuclei from a breast primary tumor showing increased DBF4 gene copy number is shown.