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. Author manuscript; available in PMC: 2008 Aug 21.
Published in final edited form as: Development. 2007 May 16;134(12):2251–2260. doi: 10.1242/dev.004929

Figure 5.

Figure 5

The regionalization of the primitive streak and the specification of the mesoderm are partially maintained in Fgf8Δb-neo/Δb-neo embryos. (A-L) In situ hybridization analysis of markers (indicated to the left) characteristic for Fgf8 signaling and mesoderm in WT and Fgf8Δb-neo/Δb-neo embryos at E7.5. (A-D and I-J) Adjacent sagittal sections of WT (A, C and I) and Fgf8Δb-neo/Δb-neo embryos (B, D and J). Inset in B shows wholemount analysis of Fgf8 expression. Note that axial mesoderm marked by T and Foxa2 expression is absent anterior to the streak of Fgf8Δb-neo/Δb-neo embryos, indicating a lack of mesoderm migration.