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. 1968 Feb;95(2):280–285. doi: 10.1128/jb.95.2.280-285.1968

Natural Antibody in Mammalian Serum Reacting with an Antigen in Some Leptospires

S Faine 1, J N Carter 1
PMCID: PMC252014  PMID: 5640374

Abstract

Serum from normal mammals agglutinated and immobilized nonpathogenic Leptospira biflexa and agglutinated avirulent lines of pathogenic serotypes L. icterohaemorrhagiae and L. zanoni. Virulent lines of L. icterohaemorrhagiae and L. zanoni were not affected, nor were any of three strains of L. pomona, one of which was avirulent. The active principle in serum was a β-macroglobulin which was heat-labile and reduced by 2-mercaptoethanol, and acted in conjunction with complement and lysozyme; it was absorbable from serum by Formalin-treated susceptible leptospires. The Formalin-stable receptor antigen, named “Z antigen,” is associated with virulence rather than pathogenicity, but may not be a determinant of virulence.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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