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Journal of Bacteriology logoLink to Journal of Bacteriology
. 1968 Feb;95(2):286–290. doi: 10.1128/jb.95.2.286-290.1968

Induced Sensitization of Normal Laboratory Animals to Brucella abortus Endotoxin1

Henry H Freedman a, Alfred E Fox a, R Suzanne Willis a, Benjamin S Schwartz a,2
PMCID: PMC252015  PMID: 4966540

Abstract

A Boivin preparation of Brucella abortus, unlike common enterobacterial endotoxins, failed to depress water intake or increase numbers of hemolysin-producing spleen cells in mice, or to cause delayed inflammatory reactions in rabbit skin. Reactivity to the B. abortus endotoxin was found only in animals which were previously given the endotoxin with, but not necessarily in, complete Freund's adjuvant. Previous treatment with the endotoxin in saline or with only the adjuvant was ineffective. Sensitization appeared within 10 days and waned after 5 weeks. Passive sensitization was obtained with sensitized donor spleen cells but not with serum. Serum antibody titers did not correlate with the appearance and disappearance of sensitization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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