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. 1968 Mar;95(3):886–892. doi: 10.1128/jb.95.3.886-892.1968

Drug Resistance of Staphylococci VI. Genetic Determinant for Chloramphenicol Resistance

Megumi Kono 1,2, Kiyoko Ogawa 1,2, Susumu Mitsuhashi 1,2
PMCID: PMC252106  PMID: 5643063

Abstract

Naturally occurring strains of staphylococci which are resistant to chloramphenicol (CM) inactivate this antibiotic. One of the inactivation products of CM showed the chromatographic behavior of 3-acetoxychloramphenicol. Induction of resistance occurred after prior exposure to subinhibitory concentrations of the antibiotic. The resistance of induced populations, as well as CM-inactivation ability, was decreased when they were grown in CM-free medium. The CM-inactivation property was transduced together with CM resistance. Transductional analysis and CM-resistance elimination experiments indicated that CM resistance in naturally occurring strains of staphylococci is mainly accounted for by inactivation of the drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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