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. 1968 Mar;95(3):1051–1055. doi: 10.21236/ad0833372

Inhibition of Staphylococcal Enterotoxin B Formation by Cell Wall Blocking Agents and other Compounds

Mischa E Friedman 1
PMCID: PMC252130  PMID: 5643046

Abstract

Enterotoxin B formation by Staphylococcus aureus S6 was inhibited by Tween 80, oleic acid, sodium deoxycholate, penicillin, d-cycloserine, or bacitracin. Toxin formation by strain 243 was sensitive to oleic acid, sodium deoxycholate, sodium lauryl sulfate, d-cycloserine, or bacitracin. The effect of d-cycloserine was reversed by d-alanine with strain 243 but not with strain S6. Neither penicillin nor bacitracin inhibited α-hemolysin or coagulase activity of strain S6; however, 0.118 μmoles of d-cycloserine per ml increased the α-hemolysin titer more than eightfold. Pigmentation of strain 243 was reduced by oleic acid, sodium deoxycholate, or methicillin, and was completely inhibited by d-cycloserine or bacitracin. Glucose was required for the inhibition by spermine of 14C-valine incorporation into cellular protein of strain S6. These data indicate that the cell surface may contain sites important to the synthesis of enterotoxin B.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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