Abstract
Three Salmonella minnesota rough mutants were found to be more sensitive to the bactericidal action of antibody and complement than was the parent smooth strain. The antibodies involved were shown to be against components which are all present in the smooth parent strain and are not identical with the lipopolysaccharides isolated by the phenol-water extraction procedure. The lipopolysaccharide of the smooth strain was shown to confer resistance by blocking access of antibody to the sensitive antigens.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bladen H. A., Gewurz H., Mergenhagen S. E. Interactions of the complement system with the surface and endotoxic lipopolysaccharide of Veillonella alcalescens. J Exp Med. 1967 May 1;125(5):767–786. doi: 10.1084/jem.125.5.767. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lüderitz O., Staub A. M., Westphal O. Immunochemistry of O and R antigens of Salmonella and related Enterobacteriaceae. Bacteriol Rev. 1966 Mar;30(1):192–255. doi: 10.1128/br.30.1.192-255.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MICHAEL J. G., WHITBY J. L., LANDY M. Studies on natural antibodies to gram-negative bacteria. J Exp Med. 1962 Jan 1;115:131–146. doi: 10.1084/jem.115.1.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROWLEY D. Rapidly induced changes in the level of non-specific immunity in laboratory animals. Br J Exp Pathol. 1956 Jun;37(3):223–234. [PMC free article] [PubMed] [Google Scholar]
- ROWLEY D., WARDLAW A. C. Lysis of gram-negative bacteria by serum. J Gen Microbiol. 1958 Apr;18(2):529–533. doi: 10.1099/00221287-18-2-529. [DOI] [PubMed] [Google Scholar]
- STERZL J., PESAK V., KOSTKA J., JILEK M. THE RELATION BETWEEN THE BACTERICIDAL ACTIVITY OF COMPLEMENT AND THE CHARACTER OF THE BACTERIAL SURFACES. Folia Microbiol (Praha) 1964 Sep;89:284–298. doi: 10.1007/BF02873307. [DOI] [PubMed] [Google Scholar]