Skip to main content
NCBI home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1968 Sep;96(3):777–784. doi: 10.1128/jb.96.3.777-784.1968

Intramolecular Heterogeneity of the Deoxyribonucleic Acid of Temperate Bacteriophages

Stanley Falkow 1, Dean B Cowie 2
PMCID: PMC252372  PMID: 4979103

Abstract

Spectral changes accompanying the thermal denaturation of phage deoxyribonucleic acid suggested that λ is not unique in possessing large-scale intramolecular heterogeneity and nucleotide clustering; instead, λ seems to share this property with other enteric phages.

Full text

PDF
777

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARON L. S., FORMAL S. B., SPILMAN W. Vi phage-host interaction in Salmonella typhosa. J Bacteriol. 1955 Feb;69(2):177–183. doi: 10.1128/jb.69.2.177-183.1955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BOICE L. B., LURIA S. E. Behavior of prophage P1 in bacterial matings. I. Transfer of the defective prophage P1 dl. Virology. 1963 May;20:147–157. doi: 10.1016/0042-6822(63)90150-8. [DOI] [PubMed] [Google Scholar]
  3. COWIE D. B., HERSHEY A. D. MULTIPLE SITES OF INTERACTION WITH HOST-CELL DNA IN THE DNA OF PHAGE LAMBDA. Proc Natl Acad Sci U S A. 1965 Jan;53:57–62. doi: 10.1073/pnas.53.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Campbell A. The steric effect in lysogenization by bacteriophage lambda. II. Chromosomal attachment of the b2 mutant. Virology. 1965 Nov;27(3):340–345. doi: 10.1016/0042-6822(65)90113-3. [DOI] [PubMed] [Google Scholar]
  5. Cohen S. N., Maitra U., Hurwitz J. Role of DNA in RNA synthesis. XI. Selective transcription of gamma DNA segments in vitro by RNA polymerase of Escherichia coli. J Mol Biol. 1967 May 28;26(1):19–38. doi: 10.1016/0022-2836(67)90258-6. [DOI] [PubMed] [Google Scholar]
  6. Cowie D. B., Szafranski P. Thermal chromatography of DNA-DNA reactions. Biophys J. 1967 Sep;7(5):567–584. doi: 10.1016/S0006-3495(67)86607-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DELEY J., VANMUYLEM J. SOME APPLICATIONS OF DEOXYRIBONUCLEIC ACID BASE COMPOSITION IN BACTERIAL TAXONOMY. Antonie Van Leeuwenhoek. 1963;29:344–358. doi: 10.1007/BF02046087. [DOI] [PubMed] [Google Scholar]
  8. Dove W. F. Action of the lambda chromosome. I. Control of functions late in bacteriophage development. J Mol Biol. 1966 Aug;19(1):187–201. doi: 10.1016/s0022-2836(66)80060-8. [DOI] [PubMed] [Google Scholar]
  9. FALKOW S., CITARELLA R. V. MOLECULAR HOMOLOGY OF F-MEROGENOTE DNA. J Mol Biol. 1965 May;12:138–151. doi: 10.1016/s0022-2836(65)80288-1. [DOI] [PubMed] [Google Scholar]
  10. Falkow S., Citarella R. V., Wohlhieter J. A. The molecular nature of R-factors. J Mol Biol. 1966 May;17(1):102–116. doi: 10.1016/s0022-2836(66)80097-9. [DOI] [PubMed] [Google Scholar]
  11. Felsenfeld G., Hirschman S. Z. A neighbor-interaction analysis of the hypochromism and spectra of DNA. J Mol Biol. 1965 Sep;13(2):407–427. doi: 10.1016/s0022-2836(65)80106-1. [DOI] [PubMed] [Google Scholar]
  12. HERSHEY A. D., BURGI E. COMPLEMENTARY STRUCTURE OF INTERACTING SITES AT THE ENDS OF LAMBDA DNA MOLECULES. Proc Natl Acad Sci U S A. 1965 Feb;53:325–328. doi: 10.1073/pnas.53.2.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hamada C., Kamiya T., Kaplan A. S. Serological analysis of some enzymes present in pseudorabies virus-infected and noninfected cells. Virology. 1966 Feb;28(2):271–281. doi: 10.1016/0042-6822(66)90151-6. [DOI] [PubMed] [Google Scholar]
  14. Hirschman S. Z., Felsenfeld G. Determination of DNA composition and concentration by spectral analysis. J Mol Biol. 1966 Apr;16(2):347–358. doi: 10.1016/s0022-2836(66)80178-x. [DOI] [PubMed] [Google Scholar]
  15. Hirschman S. Z., Gellert M., Falkow S., Felsenfeld G. Spectral analysis of the intramolecular heterogeneity of lambda-DNA. J Mol Biol. 1967 Sep 28;28(3):469–477. doi: 10.1016/s0022-2836(67)80097-4. [DOI] [PubMed] [Google Scholar]
  16. Ikeda H., Tomizawa J. I. Transducing fragments in generalized transduction by phage P1. I. Molecular origin of the fragments. J Mol Biol. 1965 Nov;14(1):85–109. doi: 10.1016/s0022-2836(65)80232-7. [DOI] [PubMed] [Google Scholar]
  17. Inman R. B. A denaturation map of the lambda phage DNA molecule determined by electron microscopy. J Mol Biol. 1966 Jul;18(3):464–476. doi: 10.1016/s0022-2836(66)80037-2. [DOI] [PubMed] [Google Scholar]
  18. Inman R. B. Denaturation maps of the left and right sides of the lambda DNA molecule determined by electron microscopy. J Mol Biol. 1967 Aug 28;28(1):103–116. doi: 10.1016/s0022-2836(67)80081-0. [DOI] [PubMed] [Google Scholar]
  19. JORDAN E. THE LOCATION OF THE B2 DELETION OF BACTERIOPHAGE LAMBDA. J Mol Biol. 1964 Nov;10:341–344. doi: 10.1016/s0022-2836(64)80052-8. [DOI] [PubMed] [Google Scholar]
  20. KAISER A. D., HOGNESS D. S. The transformation of Escherichia coli with deoxyribonucleic acid isolated from bacteriophage lambda-dg. J Mol Biol. 1960 Dec;2:392–415. doi: 10.1016/s0022-2836(60)80050-2. [DOI] [PubMed] [Google Scholar]
  21. KELLENBERGER G., ZICHICHI M. L., WEIGLE J. A mutation affecting the DNA content of bacteriophage lambda and its lysogenizing properties. J Mol Biol. 1961 Aug;3:399–408. doi: 10.1016/s0022-2836(61)80053-3. [DOI] [PubMed] [Google Scholar]
  22. MARMUR J., DOTY P. Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Mol Biol. 1962 Jul;5:109–118. doi: 10.1016/s0022-2836(62)80066-7. [DOI] [PubMed] [Google Scholar]
  23. MARMUR J., FALKOW S., MANDEL M. NEW APPROACHES TO BACTERIAL TAXONOMY. Annu Rev Microbiol. 1963;17:329–372. doi: 10.1146/annurev.mi.17.100163.001553. [DOI] [PubMed] [Google Scholar]
  24. MARMUR J., ROWND R., FALKOW S., BARON L. S., SCHILDKRAUT C., DOTY P. The nature of intergeneric episomal infection. Proc Natl Acad Sci U S A. 1961 Jul 15;47:972–979. doi: 10.1073/pnas.47.7.972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. MATSUSHIRO A., SATO K., KIDA S. CHARACTERISTICS OF THE TRANSDUCING ELEMENTS OF BACTERIOPHAGE PHI-80. Virology. 1964 Jul;23:299–306. doi: 10.1016/0042-6822(64)90251-x. [DOI] [PubMed] [Google Scholar]
  26. MATSUSHIRO A. Specialized transduction of tryptophan markers in Escherichia coli K12 by bacteriophage phi-80. Virology. 1963 Apr;19:475–482. doi: 10.1016/0042-6822(63)90041-2. [DOI] [PubMed] [Google Scholar]
  27. MIYAZAWA Y., THOMAS C. A., Jr NUCLEOTIDE COMPOSITION OF SHORT SEGMENTS OF DNA MOLECULES. J Mol Biol. 1965 Feb;11:223–237. doi: 10.1016/s0022-2836(65)80053-5. [DOI] [PubMed] [Google Scholar]
  28. Naono S., Gros F. Control and selectivity of lambda DNA transcription in lysogenic bacteria. Cold Spring Harb Symp Quant Biol. 1966;31:363–375. doi: 10.1101/sqb.1966.031.01.047. [DOI] [PubMed] [Google Scholar]
  29. Rownd R., Nakaya R., Nakamura A. Molecular nature of the drug-resistance factors of the Enterobacteriaceae. J Mol Biol. 1966 Jun;17(2):376–393. doi: 10.1016/s0022-2836(66)80149-3. [DOI] [PubMed] [Google Scholar]
  30. SCHILDKRAUT C. L., MARMUR J., DOTY P. Determination of the base composition of deoxyribonucleic acid from its buoyant density in CsCl. J Mol Biol. 1962 Jun;4:430–443. doi: 10.1016/s0022-2836(62)80100-4. [DOI] [PubMed] [Google Scholar]
  31. SUSSMAN R., JACOB F. [On a thermosensitive repression system in the Escherichia coli lambda bacteriophage]. C R Hebd Seances Acad Sci. 1962 Feb 19;254:1517–1519. [PubMed] [Google Scholar]
  32. Skalka A. Regional and temporal control of genetic transcription in phage lambda. Proc Natl Acad Sci U S A. 1966 May;55(5):1190–1195. doi: 10.1073/pnas.55.5.1190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Thomas C. A., Jr The arrangement of information in DNA molecules. J Gen Physiol. 1966 Jul;49(6):143–169. doi: 10.1085/jgp.49.6.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Yamagishi H., Yoshizako F. Characteristics of DNA molecules extracted from bacteriophages phi-80 and phi-80-pt. Virology. 1966 Sep;30(1):29–35. doi: 10.1016/s0042-6822(66)81006-1. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES