Abstract
Trehalose-6,6-dimycolate, a toxic lipid derived from tubercle bacilli, injected intravenously into mice in 10% emulsions of Bayol F caused a three- to fourfold increase in the weights of lungs compared with those of mice injected with emulsions of Bayol F alone or emulsions of Wax D. This change is due to a heavy infiltration of the lungs with granulocytes and large numbers of macrophages, with formation in some of the infiltrates of round foci, resembling granulomas.
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- Adam A., Senn M., Vilkas E., Lederer E. Spectrométrie de masse de glycolipides. 2. Diesters de tréhalose naturels et synthétiques. Eur J Biochem. 1967 Nov;2(4):460–468. doi: 10.1111/j.1432-1033.1967.tb00160.x. [DOI] [PubMed] [Google Scholar]
- BLOCH H., DEFAYE J., LEDERER E., NOLL H. Constituents of a toxic-lipid obtained from Mycobacterium tuberculosis. Biochim Biophys Acta. 1957 Feb;23(2):312–321. doi: 10.1016/0006-3002(57)90333-5. [DOI] [PubMed] [Google Scholar]
- Barclay W. R., Anacker R., Brehmer W., Ribi E. Effects of oil-treated mycobacterial cell walls on the organs of mice. J Bacteriol. 1967 Nov;94(5):1736–1745. doi: 10.1128/jb.94.5.1736-1745.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MYRVIK Q. N., LEAKE E. S., OSHIMA S. A study of macrophages and epitheloid-like cells from granulomatous (BCG-induced) lungs of rabbits. J Immunol. 1962 Nov;89:745–751. [PubMed] [Google Scholar]
- NOLL H., BLOCH H. A toxic lipid component of the tubercle bacillus (cord factor). II. Occurrence in chloroform extracts of young and older bacterial cultures. Am Rev Tuberc. 1953 Jun;67(6):828–852. doi: 10.1164/art.1953.67.6.828. [DOI] [PubMed] [Google Scholar]
- YOUMANS G. P., YOUMANS A. S. AN ACUTE PULMONARY GRANULOMATOUS RESPONSE IN MICE PRODUCED BY MYCOBACTERIAL CELLS AND ITS RELATION TO INCREASED RESISTANCE AND INCREASED SUSCEPTIBILITY TO EXPERIMENTAL TUBERCULOUS INFECTION. J Infect Dis. 1964 Apr;114:135–151. doi: 10.1093/infdis/114.2.135. [DOI] [PubMed] [Google Scholar]