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. 1985 Oct;56(1):55–59. doi: 10.1128/jvi.56.1.55-59.1985

Cytotoxic T-cell response to respiratory syncytial virus in mice.

C R Bangham, M J Cannon, D T Karzon, B A Askonas
PMCID: PMC252469  PMID: 2411951

Abstract

The role of the humoral and cellular arms of the immune response in protection against respiratory syncytial virus (RSV) infection and in the pathogenesis of the severe forms of this disease is poorly understood. The recent demonstration that some inbred mouse strains can be infected with RSV has opened the way to a detailed investigation of RSV immunity. We report here the finding of major histocompatibility complex-restricted, RSV-specific memory cytotoxic T cells in the spleens of BALB/c and C57BL mice after intranasal infection; these T cells recognize the Long, A2, and 8/60 (human) strains of RSV. Both K and D locus major histocompatibility complex alleles can restrict the cytotoxic response; however, in the two haplotypes tested, Dd is a low-responder allele and Kb is a nonresponder allele for RSV. UV-inactivated RSV (when given intraperitoneally) can prime mice for development of cytotoxic T cell memory, restimulate cytotoxic T cell cultures in vitro, and form a target for the cytotoxic cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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