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. 1968 Dec;96(6):1931–1934. doi: 10.1128/jb.96.6.1931-1934.1968

Effect of Immunosuppressive Agents on Normal Phage-neutralizing Antibody in the Mouse

R D Karp a, S G Bradley a,1
PMCID: PMC252531  PMID: 5724964

Abstract

The actions of three immunosuppressive drugs on normal antibody synthesis in the adult mouse were determined. Inbred mice were given daily intraperitoneal injections of actinomycin D, uracil mustard, or cyclophosphamide for extended periods. The sera of treated and untreated mice were assayed for phage-neutralizing activity to monitor the effect of each drug on the amount of circulating normal antibody. Except for an initial decrease in titer of normal anti-phage MSP2 activity, actinomycin D had no significant effect on normal antibody activity. Uracil mustard caused alternating elevation and depression of normal antibody titers. Cyclophosphamide caused a prolonged depression of normal antibody. The response patterns to the three immunosuppressive agents were the same for both induced and normal antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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