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. 1985 Oct;56(1):317–319. doi: 10.1128/jvi.56.1.317-319.1985

Demonstration of an immunodominant neutralization site by analysis of antigenic variants of SA11 rotavirus.

I Lazdins, S Sonza, M L Dyall-Smith, B S Coulson, I H Holmes
PMCID: PMC252539  PMID: 2993661

Abstract

Serotype-specific monoclonal antibodies were used to select mutants of SA11 rotavirus that were resistant to neutralization. The antigenic characteristics of these mutants were studied with with a panel of monoclonal antibodies. We isolated one type of mutant which showed a dramatic increase (greater than 10-fold) in resistance to neutralization by hyperimmune antiserum, and this together with other data indicates the presence on the rotavirus major outer shell glycoprotein of an immunodominant antigenic site involved in virus neutralization. The mutants were also useful in classifying neutralizing monoclonal antibodies.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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