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. 1985 Nov;56(2):426–433. doi: 10.1128/jvi.56.2.426-433.1985

Amplification of rabies virus-induced stimulation of human T-cell lines and clones by antigen-specific antibodies.

E Celis, T J Wiktor, B Dietzschold, H Koprowski
PMCID: PMC252596  PMID: 3877176

Abstract

The effect of antigen-specific antibodies on the response of human T-cell lines and clones to rabies virus was studied. Plasmas from rabies-immune vaccine recipients, but not those from nonimmune individuals, enhanced the proliferative response of rabies-reactive T cells to whole inactivated virus or to the purified glycoprotein and nucleocapsid from the rabies virion. Rabies-immune plasma also increased the antigen-induced production of gamma interferon by the rabies-specific T-cell lines. Experiments performed on T-cell clones specific for either rabies glycoprotein or nucleocapsid showed that immune plasma as well as antiglycoprotein and antinucleoprotein murine monoclonal antibodies possessed the capacity to increase significantly the antigen-induced proliferative responses of these clones. The overall results indicate that this in vitro effect of antigen-specific antibodies on the response of regulatory T lymphocytes to rabies virus could be an important factor in the development of effective immune responses in vivo to rabies virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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