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. 1986 Jan;57(1):376–378. doi: 10.1128/jvi.57.1.376-378.1986

Identification of the two rotavirus genes determining neutralization specificities.

P A Offit, G Blavat
PMCID: PMC252740  PMID: 3001359

Abstract

Bovine rotavirus NCDV and simian rotavirus SA-11 represent two distinct rotavirus serotypes. A genetic approach was used to determine which viral gene segments segregated with serotype-specific viral neutralization. There were 16 reassortant rotaviruses derived by coinfection of MA-104 cells in vitro with the SA-11 and NCDV strains. The parental origin of reassortant rotavirus double-stranded RNA segments was determined by gene segment mobility in polyacrylamide gels and by hybridization with radioactively labeled parental viral transcripts. We found that two rotavirus gene segments found previously to code for outer capsid proteins vp3 and vp7 cosegregated with virus neutralization specificities.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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