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. 1986 Mar;57(3):1203–1206. doi: 10.1128/jvi.57.3.1203-1206.1986

Neonatal respiratory syncytial virus infection: role of transplacentally and breast milk-acquired antibodies.

D T Wong, P L Ogra
PMCID: PMC252862  PMID: 3512852

Abstract

The effect of transplacentally and breast milk-acquired antibodies on respiratory syncytial virus infection was studied in neonatal and 2-month-old cotton rats. Adult female rats infected intranasally with live virus regularly produced virus-specific antibodies in the serum, colostrum, and breast milk. By using foster feeding techniques, we showed that both transplacentally and breast milk-acquired antibodies were effective in reducing the replication of respiratory syncytial virus in the lungs of neonatal animals when they were challenged with live virus via the nasal route at 3 days of age. However, the protection provided by these antibodies was rather brief. There was no difference in the replication of respiratory syncytial virus in the lungs of 2-month-old animals that were delivered and nursed by seropositive (immunized) or seronegative (control) cotton rats.

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Selected References

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