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. 1986 Apr;58(1):36–42. doi: 10.1128/jvi.58.1.36-42.1986

Pathogenicity in mice of herpes simplex virus type 2 mutants unable to express glycoprotein C.

D C Johnson, M R McDermott, C Chrisp, J C Glorioso
PMCID: PMC252873  PMID: 3005656

Abstract

Herpes simplex virus type 2 (HSV-2) mutants that were unable to express glycoprotein C (gC-2) were isolated. Deletions were made in a cloned copy of the gC-2 gene, and recombinant viruses containing these deletions were screened by using an immunoreactive plaque selection protocol. The viruses did not display a syncytial phenotype. Intravaginal inoculation of BALB/cJ mice with one of the HSV-2 gC-2- viruses produced local inflammation followed by a lethal spread of the viral infection into the nervous system in a manner identical to that produced by parental HSV-2 strain 333. Similarly, intracerebral inoculation of DBA-2 mice with the gC-2- virus produced a lethal neurological disease paralleling that caused by HSV-2 strain 333. These results indicate that gC-2 is not required for the spread of HSV-2 infections in mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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