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. 1986 Sep;59(3):728–730. doi: 10.1128/jvi.59.3.728-730.1986

Antibody to mouse alpha/beta interferon abrogates Pichinde virus-induced liver lesions in suckling mice.

T Clark, I Gresser, C Pfau, J Moss, D Woodrow
PMCID: PMC253249  PMID: 3016334

Abstract

Infection of newborn C3HeB/FeJ mice with the arenavirus Pichinde resulted in stunted growth, severe liver cell degeneration, and death. Administration of sheep anti-mouse alpha/beta interferon globulin completely abrogated liver lesions in virus-infected mice, although it did not decrease the incidence of mortality. These results indicate that endogenous interferon may be responsible for some manifestations of viral disease.

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Selected References

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