Abstract
Bone marrow cells and thymocytes isolated from virus-infected or interferon (IFN)-treated mice had marked increases in sensitivity to lysis by allospecific cytotoxic T lymphocytes (CTL) and in expression of class I histocompatibility antigens. Cultured fibroblasts treated with IFN in vitro yielded similar findings in addition to having increased sensitivity to lysis by virus-specific CTL. This indicates that virus-induced IFN may condition target cells in vivo for surveillance by CTL.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Biron C. A., Turgiss L. R., Welsh R. M. Increase in NK cell number and turnover rate during acute viral infection. J Immunol. 1983 Sep;131(3):1539–1545. [PubMed] [Google Scholar]
- Blanden R. V., Mims C. A. Macrophage activation in mice infected with ectromelia or lymphocytic choriomeningitis viruses. Aust J Exp Biol Med Sci. 1973 Jun;51(3):393–398. doi: 10.1038/icb.1973.35. [DOI] [PubMed] [Google Scholar]
- Bukowski J. F., Biron C. A., Welsh R. M. Elevated natural killer cell-mediated cytotoxicity, plasma interferon, and tumor cell rejection in mice persistently infected with lymphocytic choriomeningitis virus. J Immunol. 1983 Aug;131(2):991–996. [PubMed] [Google Scholar]
- Bukowski J. F., Welsh R. M. Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells. J Exp Med. 1985 Jan 1;161(1):257–262. doi: 10.1084/jem.161.1.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cerottini J. C., Engers H. D., Macdonald H. R., Brunner T. Generation of cytotoxic T lymphocytes in vitro. I. Response of normal and immune mouse spleen cells in mixed leukocyte cultures. J Exp Med. 1974 Sep 1;140(3):703–717. doi: 10.1084/jem.140.3.703. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cole G. A., Nathanson N., Prendergast R. A. Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. Nature. 1972 Aug 11;238(5363):335–337. doi: 10.1038/238335a0. [DOI] [PubMed] [Google Scholar]
- Hansson M., Kiessling R., Andersson B., Welsh R. M. Effect of interferon and interferon inducers on the NK sensitivity of normal mouse thymocytes. J Immunol. 1980 Nov;125(5):2225–2231. [PubMed] [Google Scholar]
- Herberman R. B., Nunn M. E., Holden H. T., Staal S., Djeu J. Y. Augmentation of natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic target cells. Int J Cancer. 1977 Apr 15;19(4):555–564. doi: 10.1002/ijc.2910190417. [DOI] [PubMed] [Google Scholar]
- Lindahl P., Gresser I., Leary P., Tovey M. Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1284–1287. doi: 10.1073/pnas.73.4.1284. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macfarlan R. I., Burns W. H., White D. O. Two cytotoxic cells in peritoneal cavity of virus-infected mice: antibody-dependent macrophages and nonspecific killer cells. J Immunol. 1977 Nov;119(5):1569–1574. [PubMed] [Google Scholar]
- Milton A. D., Fabre J. W. Massive induction of donor-type class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat. J Exp Med. 1985 Jan 1;161(1):98–112. doi: 10.1084/jem.161.1.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pfau C. J., Gresser I., Hunt K. D. Lethal role of interferon in lymphocytic choriomeningitis virus-induced encephalitis. J Gen Virol. 1983 Aug;64(Pt 8):1827–1830. doi: 10.1099/0022-1317-64-8-1827. [DOI] [PubMed] [Google Scholar]
- Saron M. F., Riviere Y., Hovanessian A. G., Guillon J. C. Chronic production of interferon in carrier mice congenitally infected with lymphocytic choriomeningitis virus. Virology. 1982 Feb;117(1):253–256. doi: 10.1016/0042-6822(82)90524-4. [DOI] [PubMed] [Google Scholar]
- Schultz R. M., Chirigos M. A. Selective neutralization by antiinterferon globulin of macrophage activation by L-cell interferon, Brucella abortus ether extract, Salmonella typhimurium lipopolysaccharide, and polyanions. Cell Immunol. 1979 Nov;48(1):52–58. doi: 10.1016/0008-8749(79)90098-4. [DOI] [PubMed] [Google Scholar]
- Skoskiewicz M. J., Colvin R. B., Schneeberger E. E., Russell P. S. Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon. J Exp Med. 1985 Nov 1;162(5):1645–1664. doi: 10.1084/jem.162.5.1645. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Trinchieri G., Santoli D. Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis. J Exp Med. 1978 May 1;147(5):1314–1333. doi: 10.1084/jem.147.5.1314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Welsh R. M., Jr Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction. J Exp Med. 1978 Jul 1;148(1):163–181. doi: 10.1084/jem.148.1.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Welsh R. M., Jr, Zinkernagel R. M. Heterospecific cytotoxic cell activity induced during the first three days of acute lymphocytic choriomeningitis virus infection in mice. Nature. 1977 Aug 18;268(5621):646–648. doi: 10.1038/268646a0. [DOI] [PubMed] [Google Scholar]
- Wong G. H., Bartlett P. F., Clark-Lewis I., Battye F., Schrader J. W. Inducible expression of H-2 and Ia antigens on brain cells. Nature. 1984 Aug 23;310(5979):688–691. doi: 10.1038/310688a0. [DOI] [PubMed] [Google Scholar]
- Yang H., Welsh R. M. Induction of alloreactive cytotoxic T cells by acute virus infection of mice. J Immunol. 1986 Feb 15;136(4):1186–1193. [PubMed] [Google Scholar]
- Zinkernagel R. M., Doherty P. C. H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;. J Exp Med. 1975 Jun 1;141(6):1427–1436. doi: 10.1084/jem.141.6.1427. [DOI] [PMC free article] [PubMed] [Google Scholar]