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. 1986 Sep;59(3):764–767. doi: 10.1128/jvi.59.3.764-767.1986

Chromosomal organization of the herpes simplex virus genome during acute infection of the mouse central nervous system.

M I Muggeridge, N W Fraser
PMCID: PMC253259  PMID: 3016340

Abstract

After corneal inoculation, herpes simplex virus type 1 replicates in the mouse eye, trigeminal ganglia, and brainstem, producing first an acute and then a latent infection. Previous work from this laboratory focused on the structure of the viral DNA in this system. We have now examined the structure of the viral genome at the chromosome level by using micrococcal nuclease digestion. Studies with disaggregated cell preparations made from the brainstems of acutely infected mice show that the majority of the viral DNA is in a nonnucleosomal form; however, a nucleosomelike fraction was also consistently detected. A similar result was obtained for viral DNA in herpes simplex virus type 1-infected C1300 (clone NA) neuroblastoma cells (a neuronal cell line).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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