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Journal of Virology logoLink to Journal of Virology
. 1988 Sep;62(9):3530–3535. doi: 10.1128/jvi.62.9.3530-3535.1988

Thymidylate synthase gene of herpesvirus ateles.

J Richter 1, I Puchtler 1, B Fleckenstein 1
PMCID: PMC253484  PMID: 3404583

Abstract

The putative thymidylate synthase (TS) gene of herpesvirus ateles, a T-lymphotropic tumor virus of New World primates, has a single large open reading frame encoding a polypeptide of 32.9 kilodaltons. The gene is transcribed into an unspliced 2.4-kilobase mRNA that is abundantly expressed late in virus replication. The AT-rich 5' untranslated leader sequence of TS mRNA in herpesvirus ateles-infected cells is remarkable in length (1,184 nucleotides), containing 29 minicistrons; this may indicate a role in translation regulation.

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Selected References

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