Skip to main content
NCBI home page
Journal of Virology logoLink to Journal of Virology
. 1988 Oct;62(10):3862–3866. doi: 10.1128/jvi.62.10.3862-3866.1988

Genetic polymorphism of natural Epstein-Barr virus isolates from infectious mononucleosis patients and healthy carriers.

M L Lung 1, R S Chang 1, J H Jones 1
PMCID: PMC253533  PMID: 2901499

Abstract

We analyzed Epstein-Barr virus (EBV) genomes from lymphoblastoid cell lines isolated from patients with infectious mononucleosis and from healthy subjects from California, Hawaii, and Hong Kong between 1970 and 1987. Using genetic polymorphism as epidemiological markers, we found that several genotypes of EBV cocirculate in a community and that although most EBV strains isolated from California and Southern China may be differentiated genotypically, there was no specific association between genotype and disease or time of isolation.

Full text

PDF
3862

Images in this article

3863Image
on p.3863
3864Image
on p.3864
3864Image
on p.3864
3864Image
on p.3864
3865Image
on p.3865
3865Image
on p.3865

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bird A. G., McLachlan S. M. Cyclosporin A and Epstein-Barr virus. Lancet. 1980 Aug 23;2(8191):418–418. doi: 10.1016/s0140-6736(80)90457-2. [DOI] [PubMed] [Google Scholar]
  2. Bornkamm G. W., von Knebel-Doeberitz M., Lenoir G. M. No evidence for differences in the Epstein-Barr virus genome carried in Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from the same patients. Proc Natl Acad Sci U S A. 1984 Aug;81(15):4930–4934. doi: 10.1073/pnas.81.15.4930. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chang R. S., Char D. F., Jones J. H., Halstead S. B. Incidence of infectious mononucleosis at the Universities of California and Hawaii. J Infect Dis. 1979 Oct;140(4):479–486. doi: 10.1093/infdis/140.4.479. [DOI] [PubMed] [Google Scholar]
  4. Chang R. S., Cooper T. Y., Simpson E. E. Letter: Epstein-Barr viral antibodies and leukocyte-transforming agent in infectious mononucleosis. N Engl J Med. 1976 Jun 17;294(25):1404–1405. doi: 10.1056/NEJM197606172942517. [DOI] [PubMed] [Google Scholar]
  5. Chang R. S. Letter: Interpersonal transmission of EB-virus infection. N Engl J Med. 1975 Aug 28;293(9):454–455. doi: 10.1056/NEJM197508282930915. [DOI] [PubMed] [Google Scholar]
  6. Chang R. S., Lewis J. P., Abildgaard C. F. Prevalence of oropharyngeal excreters of leukocyte-transforming agents among a human population. N Engl J Med. 1973 Dec 20;289(25):1325–1329. doi: 10.1056/NEJM197312202892501. [DOI] [PubMed] [Google Scholar]
  7. Chang R. S., Lewis J. P., Reynolds R. D., Sullivan M. J., Neuman J. Oropharyngeal excretion of Epstein-Barr virus by patients with lymphoproliferative disorders and by recipients of renal homografts. Ann Intern Med. 1978 Jan;88(1):34–40. doi: 10.7326/0003-4819-88-1-34. [DOI] [PubMed] [Google Scholar]
  8. Chang R. S., Thompson H., Pomerantz S. Epstein-Barr virus infections in homosexual men with chronic, persistent generalized lymphadenopathy. J Infect Dis. 1985 Mar;151(3):459–463. doi: 10.1093/infdis/151.3.459. [DOI] [PubMed] [Google Scholar]
  9. Dambaugh T., Raab-Traub N., Heller M., Beisel C., Hummel M., Cheung A., Fennewald S., King W., Kieff E. Variations among isolates of Epstein-Barr virus. Ann N Y Acad Sci. 1980;354:309–325. doi: 10.1111/j.1749-6632.1980.tb27974.x. [DOI] [PubMed] [Google Scholar]
  10. Freese U. K., Laux G., Hudewentz J., Schwarz E., Bornkamm G. W. Two distant clusters of partially homologous small repeats of Epstein-Barr virus are transcribed upon induction of an abortive or lytic cycle of the virus. J Virol. 1983 Dec;48(3):731–743. doi: 10.1128/jvi.48.3.731-743.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gergely L., Sternås L., Dillner J., Klein G. Molecular size variation of EBNA is determined by the EB viral genome. Intervirology. 1984;22(2):85–96. doi: 10.1159/000149538. [DOI] [PubMed] [Google Scholar]
  12. Golden H. D., Chang R. S., Prescott W., Simpson E., Cooper T. Y. Leukocyte-transforming agent: prolonged excretion by patients with mononucleosis and excretion by normal individuals. J Infect Dis. 1973 Apr;127(4):471–473. doi: 10.1093/infdis/127.4.471. [DOI] [PubMed] [Google Scholar]
  13. Heller M., Dambaugh T., Kieff E. Epstein-Barr virus DNA. IX. Variation among viral DNAs from producer and nonproducer infected cells. J Virol. 1981 May;38(2):632–648. doi: 10.1128/jvi.38.2.632-648.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Heller M., van Santen V., Kieff E. Simple repeat sequence in Epstein-Barr virus DNA is transcribed in latent and productive infections. J Virol. 1982 Oct;44(1):311–320. doi: 10.1128/jvi.44.1.311-320.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hennessy K., Heller M., van Santen V., Kieff E. Simple repeat array in Epstein-Barr virus DNA encodes part of the Epstein-Barr nuclear antigen. Science. 1983 Jun 24;220(4604):1396–1398. doi: 10.1126/science.6304878. [DOI] [PubMed] [Google Scholar]
  16. Hennessy K., Kieff E. One of two Epstein-Barr virus nuclear antigens contains a glycine-alanine copolymer domain. Proc Natl Acad Sci U S A. 1983 Sep;80(18):5665–5669. doi: 10.1073/pnas.80.18.5665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hudewentz J., Delius H., Freese U. K., Zimber U., Bornkamm G. W. Two distant regions of the Epstein-Barr virus genome with sequence homologies have the same orientation and involve small tandem repeats. EMBO J. 1982;1(1):21–26. doi: 10.1002/j.1460-2075.1982.tb01118.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Katz B. Z., Andiman W. A., Eastman R., Martin K., Miller G. Infection with two genotypes of Epstein-Barr virus in an infant with AIDS and lymphoma of the central nervous system. J Infect Dis. 1986 Mar;153(3):601–604. doi: 10.1093/infdis/153.3.601. [DOI] [PubMed] [Google Scholar]
  19. Katz B. Z., Niederman J. C., Olson B. A., Miller G. Fragment length polymorphisms among independent isolates of Epstein-Barr virus from immunocompromised and normal hosts. J Infect Dis. 1988 Feb;157(2):299–308. doi: 10.1093/infdis/157.2.299. [DOI] [PubMed] [Google Scholar]
  20. Miller G., Grogan E., Rowe D., Rooney C., Heston L., Eastman R., Andiman W., Niederman J., Lenoir G., Henle W. Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection. J Infect Dis. 1987 Jul;156(1):26–35. doi: 10.1093/infdis/156.1.26. [DOI] [PubMed] [Google Scholar]
  21. Nilsson K., Klein G., Henle W., Henle G. The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV. Int J Cancer. 1971 Nov 15;8(3):443–450. doi: 10.1002/ijc.2910080312. [DOI] [PubMed] [Google Scholar]
  22. Raab-Traub N., Dambaugh T., Kieff E. DNA of Epstein-Barr virus VIII: B95-8, the previous prototype, is an unusual deletion derivative. Cell. 1980 Nov;22(1 Pt 1):257–267. doi: 10.1016/0092-8674(80)90173-7. [DOI] [PubMed] [Google Scholar]
  23. Rigby P. W., Dieckmann M., Rhodes C., Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol. 1977 Jun 15;113(1):237–251. doi: 10.1016/0022-2836(77)90052-3. [DOI] [PubMed] [Google Scholar]
  24. Sculley T. B., Moss D. J., Hazelton R. A., Pope J. H. Detection of Epstein-Barr virus strain variants in lymphoblastoid cell lines 'spontaneously' derived from patients with rheumatoid arthritis, infectious mononucleosis and normal controls. J Gen Virol. 1987 Aug;68(Pt 8):2069–2078. doi: 10.1099/0022-1317-68-8-2069. [DOI] [PubMed] [Google Scholar]
  25. Sixbey J. W., Nedrud J. G., Raab-Traub N., Hanes R. A., Pagano J. S. Epstein-Barr virus replication in oropharyngeal epithelial cells. N Engl J Med. 1984 May 10;310(19):1225–1230. doi: 10.1056/NEJM198405103101905. [DOI] [PubMed] [Google Scholar]
  26. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  27. Zimber U., Adldinger H. K., Lenoir G. M., Vuillaume M., Knebel-Doeberitz M. V., Laux G., Desgranges C., Wittmann P., Freese U. K., Schneider U. Geographical prevalence of two types of Epstein-Barr virus. Virology. 1986 Oct 15;154(1):56–66. doi: 10.1016/0042-6822(86)90429-0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES