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. 1988 Oct;62(10):3914–3917. doi: 10.1128/jvi.62.10.3914-3917.1988

Inhibition of human immunodeficiency virus by using an oligonucleoside methylphosphonate targeted to the tat-3 gene.

J A Zaia 1, J J Rossi 1, G J Murakawa 1, P A Spallone 1, D A Stephens 1, B E Kaplan 1, R Eritja 1, R B Wallace 1, E M Cantin 1
PMCID: PMC253546  PMID: 2458490

Abstract

Antiviral effects were characterized for two oligodeoxyribonucleoside methylphosphonates synthesized in an antisense (3'-TCTTAACC-5') or a sense (5'-AGAATTGG-3') orientation, based on the RNA sequence of the first splice acceptor site of the tat-3 gene of human immunodeficiency virus (HIV) (5'...AGAAUUGG...3'). The development of syncytial cells and supernatant reverse transcriptase was inhibited by a single exposure to the antisense HIV, and HIV RNA synthesis was inhibited by both antisense and sense methylphosphonates but not by a control herpes simplex virus antisense sequence.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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