Figure 1.—
The p53 effect on tumorigenesis in Apc mutants was observed with different Apc and p53 alleles. Crosses between B6 congenic strains were performed to test the interaction between Apc1638N and p53BCM (A and B: P = 2.2 × 10−5 and P = 2.4 × 10−5, respectively) or to test the interaction between ApcMin and p53tm1TyjJ (C and D: P = 0.003 and P = 7.8 × 10−4, respectively). Progeny homozygous for the mutant p53 allele were sacrificed at 100 days of age. The total numbers of intestinal tumors (A and C) and desmoid fibromas (B and D) were scored for each mouse.