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. 1988 Dec;62(12):4767–4769. doi: 10.1128/jvi.62.12.4767-4769.1988

The putative trans-activator in the MAgag region of Rous sarcoma virus is not required for cell transformation.

A Dutta 1, T Dorai 1, H Hanafusa 1
PMCID: PMC253595  PMID: 2846886

Abstract

A stop codon created by oligonucleotide-directed mutagenesis in the proposed transcriptional trans-activator of Rous sarcoma virus (S. Broome and W. Gilbert, Cell 40:537-546, 1985) which truncated the trans-activator by half did not alter the transforming activity or the replication of the virus in primary chicken embryo fibroblasts. This result proves that this trans-activator is not essential for transformation of primary cells by Rous sarcoma virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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