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. 1988 Dec;62(12):4770–4773. doi: 10.1128/jvi.62.12.4770-4773.1988

Tumorigenic potential of a myc-containing strain of feline leukemia virus in vivo in domestic cats.

L S Levy 1, R E Fish 1, G B Baskin 1
PMCID: PMC253596  PMID: 2846887

Abstract

The oncogenic capacity of a myc-containing strain of feline leukemia virus (FeLV), termed LC-FeLV, has been examined after inoculation of the virus into neonatal kittens. Like other myc-containing strains of FeLV, LC-FeLV may induce with relatively short latency, but does not necessarily induce, thymic lymphosarcoma in viremic animals. Naturally occurring and experimentally induced tumors are T-cell lymphomas which contain clonally integrated LC-FeLV proviral DNA and which cannot readily be cultivated in vitro in the presence or absence of exogenously supplied interleukin-2. Acquisition of myc by FeLV decreases the period of latency before the appearance of tumors but does not expand the spectrum of tumors induced by FeLV alone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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