Abstract
An immunization trial carried out on 1310 persons professionally exposed to Q fever confirmed the suitability of a chemovaccine for field use. Its immunogenicity and reactogenicity differed in three groups of subjects who differed in their previous experience of Q fever and who were given different lots of the vaccine. There was some correlation between reactogenicity of the vaccine and pre-immunization positivity in the microagglutination and skin tests as indicators of a previous exposure. The skin test was more reliable for predicting post-immunization reactions.
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- BERMAN S., COLE G., LOWENTHAL J. P., GOCHENOUR R. B. Safety test for Q fever vaccine. J Bacteriol. 1960 May;79:747–751. doi: 10.1128/jb.79.5.747-751.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brezina R., Murray E. S., Tarizzo M. L., Bögel K. Rickettsiae and rickettsial diseases. Bull World Health Organ. 1973;49(5):433–442. [PMC free article] [PubMed] [Google Scholar]
- Crăcea E., Dumitrescu-Constantinescu S., Botez D., Ioanid L. Q-fever soluble vaccine effects in Coxiella burneti sensitized humans. Zentralbl Bakteriol Orig A. 1977 Jul;238(3):413–418. [PubMed] [Google Scholar]
- Crăcea E., Dumitrescu S., Botez D., Toma E., Bandu C., Sabin S., Ioanid L., Chirescu N. Immunization in man with a soluble Q fever vaccine. Arch Roum Pathol Exp Microbiol. 1973 Mar;32(1):45–51. [PubMed] [Google Scholar]
- D'Angelo L. J., Baker E. F., Schlosser W. From the Center for Disease Control: Q fever in the United States, 1948--1977. J Infect Dis. 1979 May;139(5):613–615. doi: 10.1093/infdis/139.5.613. [DOI] [PubMed] [Google Scholar]
- Genig V. A., Kniazeva E. N., Tsel'nikov P. S., Miroshnichenko M. M. Opyt massovoi immunizatsii liudei zhivoi vaktsinoi M-44 protiv Ku likhoradki. I. Podkozhnyi metod immunizatsii. Vopr Virusol. 1965 May-Jun;10(3):319–323. [PubMed] [Google Scholar]
- Johnson J. W., Eddy G. A., Pedersen C. E., Jr Biological properties of the M-44 strain of Coxiella burneti. J Infect Dis. 1976 Mar;133(3):334–338. doi: 10.1093/infdis/133.3.334. [DOI] [PubMed] [Google Scholar]
- Johnson J. W., McLeod C. G., Stookey J. L., Higbee G. A., Pedersen C. E., Jr Lesions in guinea pigs infected with Coxiella burnetii strain M-44. J Infect Dis. 1977 Jun;135(6):995–998. doi: 10.1093/infdis/135.6.995. [DOI] [PubMed] [Google Scholar]
- Kazár J., Brezina R., Schramek S., Palanová A., Tvrdá B. Suitability of the microagglutination test for detection of post-infection and post-vaccination Q fever antibodies in human sera. Acta Virol. 1981 Jul;25(4):235–240. [PubMed] [Google Scholar]
- Marmion B. P. Development of Q-fever vaccines, 1937 to 1967. Med J Aust. 1967 Dec 9;2(24):1074–1078. doi: 10.5694/j.1326-5377.1967.tb27293.x. [DOI] [PubMed] [Google Scholar]
- ORMSBEE R. A., BELL E. J., LACKMAN D. B., TALLENT G. THE INFLUENCE OF PHASE ON THE PROTECTIVE POTENCY OF Q FEVER VACCINE. J Immunol. 1964 Mar;92:404–412. [PubMed] [Google Scholar]
- Schramek S., Brezina R., Pospísil V. Improved method of preparing phase II Coxiella burneti antigen for the microagglutination test. Acta Virol. 1970 Sep;14(5):415–415. [PubMed] [Google Scholar]
- Sen G. P., De S., Chakravorty A. K., Saha S. C., Bera A., Khanna P. N. Sero-epidemiological evidence of Coxiella burnetii infection among selected human population in Calcutta. Indian J Med Res. 1978 Dec;68:911–916. [PubMed] [Google Scholar]
- VIVONA S., LOWENTHAL J. P., BERMAN S., BENENSON A. S., SMADEL J. E. REPORT OF A FIELD STUDY WITH Q FEVER VACCINE. Am J Hyg. 1964 Mar;79:143–153. doi: 10.1093/oxfordjournals.aje.a120370. [DOI] [PubMed] [Google Scholar]
- Vanek E., Thimm B. Q fever in Kenya. Serological investigations in man and domestic animals. East Afr Med J. 1976 Dec;53(12):678–684. [PubMed] [Google Scholar]
- de Ruiz H. L. Q fever in Colombia, S.A. A serological survey of human and bovine populations. Zentralbl Veterinarmed B. 1977;24(4):287–292. doi: 10.1111/j.1439-0450.1977.tb01000.x. [DOI] [PubMed] [Google Scholar]