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. 1985;63(1):101–108.

Chloroquine-resistant falciparum malaria imported into the Netherlands*

J C F M Wetsteyn, A de Geus
PMCID: PMC2536346  PMID: 3886183

Abstract

A prospective study of imported chloroquine-resistant falciparum malaria in the Netherlands is described. From 1979 to 1983, 77 non-immune patients were investigated; in 41 (53%) decreased sensitivity of Plasmodium falciparum to chloroquine could be confirmed. Signs and symptoms in these patients differ from the classical picture. Resistance to sulfadoxine—pyrimethamine (Fansidar) was established in 6 patients. Parasitaemia was found twice during dapsone—pyrimethamine (Maloprim) prophylaxis. The implications for advice on treatment and prophylaxis are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brohult J., Rombo L., Sirleaf V., Bengtsson E. The concentration of chloroquine in serum during short and long term malaria prophylaxis with standard and 'double' dosage in non-immunes: clinical implications. Ann Trop Med Parasitol. 1979 Oct;73(5):401–405. doi: 10.1080/00034983.1979.11687279. [DOI] [PubMed] [Google Scholar]
  2. Bruce-Chwatt L. J. Chemoprophylaxis of malaria in Africa: the spent "magic bullet". Br Med J (Clin Res Ed) 1982 Sep 11;285(6343):674–676. doi: 10.1136/bmj.285.6343.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Campbell C. C., Chin W., Collins W. E., Teutsch S. M., Moss D. M. Chloroquine-resistant Plasmodium falciparum from East Africa: cultivation and drug sensitivity of the Tanzanian I/CDC strain from an American tourist. Lancet. 1979 Dec 1;2(8153):1151–1154. doi: 10.1016/s0140-6736(79)92383-3. [DOI] [PubMed] [Google Scholar]
  4. De Geus A., Meuwissen J. H., van Rijn A. A case of fansidar-resistant Plasmodium falciparum from Tanzania. Trop Geogr Med. 1982;34(3):261–263. [PubMed] [Google Scholar]
  5. Ebisawa I., Fukuyama T. Chloroquine resistance of Plasmodium falciparum in West Irian and East Kalimantan. Ann Trop Med Parasitol. 1975 Sep;69(3):275–282. doi: 10.1080/00034983.1975.11687011. [DOI] [PubMed] [Google Scholar]
  6. Fogh S., Jepsen S., Effersøe P. Chloroquine-resistant Plasmodium falciparum malaria in Kenya. Trans R Soc Trop Med Hyg. 1979;73(2):228–229. doi: 10.1016/0035-9203(79)90220-7. [DOI] [PubMed] [Google Scholar]
  7. Hornstein O. P., Ruprecht K. W. Fansidar-induced Stevens-Johnson Syndrome. N Engl J Med. 1982 Dec 9;307(24):1529–1530. doi: 10.1056/NEJM198212093072425. [DOI] [PubMed] [Google Scholar]
  8. Nguyen-Dinh P., Trager W. Plasmodium falciparum in vitro: determination of chloroquine sensitivity of three new strains by a modified 48-hour test. Am J Trop Med Hyg. 1980 May;29(3):339–342. doi: 10.4269/ajtmh.1980.29.339. [DOI] [PubMed] [Google Scholar]
  9. Olsen V. V., Loft S., Christensen K. D. Serious reactions during malaria prophylaxis with pyrimethamine-sulfadoxine. Lancet. 1982 Oct 30;2(8305):994–994. doi: 10.1016/s0140-6736(82)90202-1. [DOI] [PubMed] [Google Scholar]
  10. Oosterhuis B., Van den Berg M., Wetsteyn J., Van Boxtel C. J. HPLC-analysis and preliminary pharmacokinetic parameter estimations of chloroquine. Pharm Weekbl Sci. 1981 Dec 18;3(6):263–267. [PubMed] [Google Scholar]
  11. Ponnudurai T., Leeuwenberg A. D., Meuwissen J. H. Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture. Trop Geogr Med. 1981 Mar;33(1):50–54. [PubMed] [Google Scholar]
  12. Reacher M., Campbell C. C., Freeman J., Doberstyn E. B., Brandling-Bennett A. D. Drug therapy for Plasmodium falciparum malaria resistant to pyrimethamine-sulfadoxine (Fansidar). A study of alternate regimens in Eastern Thailand, 1980. Lancet. 1981 Nov 14;2(8255):1066–1069. doi: 10.1016/s0140-6736(81)91274-5. [DOI] [PubMed] [Google Scholar]
  13. Rieckmann K. H., Campbell G. H., Sax L. J., Mrema J. E. Drug sensitivity of plasmodium falciparum. An in-vitro microtechnique. Lancet. 1978 Jan 7;1(8054):22–23. doi: 10.1016/s0140-6736(78)90365-3. [DOI] [PubMed] [Google Scholar]
  14. Stahel E., Degrémont A., Lagler U. Pyrimethamine/sulfadoxine resistant falciparum malaria acquired at Dar es Salaam, Tanzania. Lancet. 1982 May 15;1(8281):1118–1119. doi: 10.1016/s0140-6736(82)92294-2. [DOI] [PubMed] [Google Scholar]
  15. Trenholme G. M., Williams R. L., Frischer H., Carson P. E., Rieckmann K. H. Host failure in treatment of malaria with sulfalene and pyrimethamine. Ann Intern Med. 1975 Feb;82(2):219–223. doi: 10.7326/0003-4819-82-2-219. [DOI] [PubMed] [Google Scholar]
  16. Vleugels M. P., Wetsteyn J. C., Meuwissen J. H. Fansidar-resistant Plasmodium falciparum infection from Tanzania. Trop Geogr Med. 1982;34(3):263–265. [PubMed] [Google Scholar]
  17. Williams R. L., Trenholme G. M., Carson P. E., Frischer H., Rieckmann K. H. Acetylator phenotype and response of individuals infected with a chloroquine-resistant strain of Plasmodium falciparum to sulfalene and pyrimethamine. Am J Trop Med Hyg. 1975 Sep;24(5):734–739. doi: 10.4269/ajtmh.1975.24.734. [DOI] [PubMed] [Google Scholar]

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