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. 1985;63(4):739–743.

Failure of large-dose erythromycin in combination with a standard dose of chloroquine or quinine in the treatment of human falciparum malaria

Lorrin W Pang, Ellen F Boudreau, George E Childs, H Kyle Webster, Chumpol Supanantalerk, Panu Somutsakorn
PMCID: PMC2536364  PMID: 3910297

Abstract

In eastern Thailand, falciparum malaria is highly chloroquine-resistant and is quickly becoming quinine-resistant. In the present study, ten patients with falciparum malaria were given large doses of erythromycin, combined with standard doses of chloroquine; the cure rate was 0 out of 10 (4 RIII failures, 6 RII failures). A further ten patients were given erythromycin with standard doses of quinine; 2 of the 10 patients were cured (8 RI failures). These regimens thus appear to have no appreciable effect against falciparum infections in eastern Thailand.

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Selected References

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