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Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1985;63(4):757–772.

Interventions for the control of diarrhoeal diseases among young children: improving water supplies and excreta disposal facilities*

S A Esrey, R G Feachem, J M Hughes
PMCID: PMC2536385  PMID: 3878742

Abstract

A theoretical model is proposed that relates the level of ingestion of diarrhoea-causing pathogens to the frequency of diarrhoea in the community. The implications of this model are that, in poor communities with inadequate water supply and excreta disposal, reducing the level of enteric pathogen ingestion by a given amount will have a greater impact on diarrhoea mortality rates than on morbidity rates, a greater impact on the incidence rate of severe diarrhoea than on that of mild diarrhoea, and a greater impact on diarrhoea caused by pathogens having high infectious doses than on diarrhoea caused by pathogens of a low infectious dose. The impact of water supply and sanitation on diarrhoea, related infections, nutritional status, and mortality is analysed by reviewing 67 studies from 28 countries. The median reductions in diarrhoea morbidity rates are 22% from all studies and 27% from a few better-designed studies. All studies of the impact on total mortality rates show a median reduction of 21%, while the few better-designed studies give a median reduction of 30%. Improvements in water quality have less of an impact than improvements in water availability or excreta disposal.

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Selected References

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  1. Ascoli W., Guzmán M. A., Scrimshaw N. S., Gordon J. E. Nutrition and infection field study in Guatemalan villages, 1959-1964. IV. Deaths of infants and preschool children. Arch Environ Health. 1967 Oct;15(4):439–449. doi: 10.1080/00039896.1967.10664945. [DOI] [PubMed] [Google Scholar]
  2. Ashworth A., Feachem R. G. Interventions for the control of diarrhoeal diseases among young children: prevention of low birth weight. Bull World Health Organ. 1985;63(1):165–184. [PMC free article] [PubMed] [Google Scholar]
  3. Azurin J. C., Alvero M. Field evaluation of environmental sanitation measures against cholera. Bull World Health Organ. 1974;51(1):19–26. [PMC free article] [PubMed] [Google Scholar]
  4. BECK M. D., MUNOZ J. A., SCRIMSHAW N. S. Studies on diarrheal diseases in Central America. I. Preliminary findings on cultural surveys of normal population groups in Guatemala. Am J Trop Med Hyg. 1957 Jan;6(1):62–71. doi: 10.4269/ajtmh.1957.6.62. [DOI] [PubMed] [Google Scholar]
  5. BILLE B., MELLBIN T., NORDBRING F. AN EXTENSIVE OUTBREAK OF GASTROENTERITIS CAUSED BY SALMONELLA NEWPORT. I. SOME OBSERVATIONS OF 745 KNOWN CASES. Acta Med Scand. 1964 May;175:557–567. doi: 10.1111/j.0954-6820.1964.tb00607.x. [DOI] [PubMed] [Google Scholar]
  6. BROOKE M. M., HEALY G. R., LEVY P., KAISER R. L., BUNCH W. L. A SAMPLE SURVEY OF SELECTED AREAS IN AND NEAR LITTLE ROCK, ARKANSAS, TO ASSESS THE PREVALENCE OF ENTAMOEBA HISTOLYTICA. Bull World Health Organ. 1963;29:813–822. [PMC free article] [PubMed] [Google Scholar]
  7. BRUCH H. A., ASCOLI W., SCRIMSHAW N. S., GORDON J. E. STUDIES OF DIARRHEAL DISEASE IN CENTRAL AMERICA. V. ENVIRONMENTAL FACTORS IN THE ORIGIN AND TRANSMISSION OF ACUTE DIARRHEAL DISEASE IN FOUR GUATEMALAN VILLAGES. Am J Trop Med Hyg. 1963 Jul;12:567–579. doi: 10.4269/ajtmh.1963.12.567. [DOI] [PubMed] [Google Scholar]
  8. Bahl M. R. Impact of piped water supply on the incidence of typhoid fever and diarrhoeal diseases in Lusaka. Med J Zambia. 1976 Aug-Sep;10(4):98–99. [PubMed] [Google Scholar]
  9. Berman P. A. Selective primary health care: is efficient sufficient? Soc Sci Med. 1982;16(10):1054–1059. doi: 10.1016/0277-9536(82)90178-2. [DOI] [PubMed] [Google Scholar]
  10. Black R. E., Merson M. H., Huq I., Alim A. R., Yunus M. Incidence and severity of rotavirus and Escherichia coli diarrhoea in rural Bangladesh. Implications for vaccine development. Lancet. 1981 Jan 17;1(8212):141–143. doi: 10.1016/s0140-6736(81)90719-4. [DOI] [PubMed] [Google Scholar]
  11. Blaser M. J., Newman L. S. A review of human salmonellosis: I. Infective dose. Rev Infect Dis. 1982 Nov-Dec;4(6):1096–1106. doi: 10.1093/clinids/4.6.1096. [DOI] [PubMed] [Google Scholar]
  12. Blum D., Feachem R. G. Measuring the impact of water supply and sanitation investments on diarrhoeal diseases: problems of methodology. Int J Epidemiol. 1983 Sep;12(3):357–365. doi: 10.1093/ije/12.3.357. [DOI] [PubMed] [Google Scholar]
  13. Briscoe J. Water supply and health in developing countries: selective primary health care revisited. Am J Public Health. 1984 Sep;74(9):1009–1013. doi: 10.2105/ajph.74.9.1009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Burr M. L., Davis A. R., Zbijowski A. G. Diarrhoea and the drought. Public Health. 1978 Mar;92(2):86–87. doi: 10.1016/s0033-3506(78)80034-1. [DOI] [PubMed] [Google Scholar]
  15. Butz W. P., Habicht J. P., DaVanzo J. Environmental factors in the relationship between breastfeeding and infant mortality: the role of sanitation and water in Malaysia. Am J Epidemiol. 1984 Apr;119(4):516–525. doi: 10.1093/oxfordjournals.aje.a113769. [DOI] [PubMed] [Google Scholar]
  16. CHANDLER A. C. A comparison of helminthic and protozoan infections in two Egyptian villages two years after the installation of sanitary improvements in one of them. Am J Trop Med Hyg. 1954 Jan;3(1):59–73. doi: 10.4269/ajtmh.1954.3.59. [DOI] [PubMed] [Google Scholar]
  17. Cash R. A., Music S. I., Libonati J. P., Snyder M. J., Wenzel R. P., Hornick R. B. Response of man to infection with Vibrio cholerae. I. Clinical, serologic, and bacteriologic responses to a known inoculum. J Infect Dis. 1974 Jan;129(1):45–52. doi: 10.1093/infdis/129.1.45. [DOI] [PubMed] [Google Scholar]
  18. Christiansen N., Mora J. O., Herrera M. G. Family social characteristics related to physical growth of young children. Br J Prev Soc Med. 1975 Jun;29(2):121–130. doi: 10.1136/jech.29.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. EYLES D. E., JONES F. E., SMITH C. S. A study of Endamoeba histolytica and other intestinal parasites in a rural West Tennessee community. Am J Trop Med Hyg. 1953 Mar;2(2):173–190. doi: 10.4269/ajtmh.1953.2.173. [DOI] [PubMed] [Google Scholar]
  20. Feachem R. G. Environmental aspects of cholera epidemiology. III. Transmission and control. Trop Dis Bull. 1982 Jan;79(1):1–47. [PubMed] [Google Scholar]
  21. Feachem R. G., Hogan R. C., Merson M. H. Diarrhoeal disease control: reviews of potential interventions. Bull World Health Organ. 1983;61(4):637–640. [PMC free article] [PubMed] [Google Scholar]
  22. Feachem R. G. Interventions for the control of diarrhoeal diseases among young children: promotion of personal and domestic hygiene. Bull World Health Organ. 1984;62(3):467–476. [PMC free article] [PubMed] [Google Scholar]
  23. Feachem R. G. Interventions for the control of diarrhoeal diseases among young children: supplementary feeding programmes. Bull World Health Organ. 1983;61(6):967–979. [PMC free article] [PubMed] [Google Scholar]
  24. Feachem R. G., Koblinsky M. A. Interventions for the control of diarrhoeal diseases among young children: measles immunization. Bull World Health Organ. 1983;61(4):641–652. [PMC free article] [PubMed] [Google Scholar]
  25. Feachem R. G., Koblinsky M. A. Interventions for the control of diarrhoeal diseases among young children: promotion of breast-feeding. Bull World Health Organ. 1984;62(2):271–291. [PMC free article] [PubMed] [Google Scholar]
  26. Feachem R. Bacterial standards for drinking water quality in developing countries. Lancet. 1980 Aug 2;2(8188):255–256. doi: 10.1016/s0140-6736(80)90139-7. [DOI] [PubMed] [Google Scholar]
  27. Ghannoum M. A., Moore K. E., Al-Dulaimi M., Nasr M. The incidence of water-related diseases in the Brak area, Libya from 1977 to 1979, before and after the installation of water treatment plants. Zentralbl Bakteriol Mikrobiol Hyg B. 1981 Sep;173(6):501–508. [PubMed] [Google Scholar]
  28. Gurwith M., Wenman W., Hinde D., Feltham S., Greenberg H. A prospective study of rotavirus infection in infants and young children. J Infect Dis. 1981 Sep;144(3):218–224. doi: 10.1093/infdis/144.3.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. HOLLISTER A. C., Jr, BECK M. D., GITTELSOHN A. M., HEMPHILL E. C. Influence of water availability on Shigella prevalence in children of farm labor families. Am J Public Health Nations Health. 1955 Mar;45(3):354–362. doi: 10.2105/ajph.45.3.354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Henry F. J. Environmental sanitation infection and nutritional status of infants in rural St. Lucia, West Indies. Trans R Soc Trop Med Hyg. 1981;75(4):507–513. doi: 10.1016/0035-9203(81)90187-5. [DOI] [PubMed] [Google Scholar]
  31. Hughes J. M., Boyce J. M., Levine R. J., Khan M., Aziz K. M., Huq M. I., Curlin G. T. Epidemiology of eltor cholera in rural Bangladesh: importance of surface water in transmission. Bull World Health Organ. 1982;60(3):395–404. [PMC free article] [PubMed] [Google Scholar]
  32. Khan M. U., Mosley W. H., Chakraborty J., Majid Sarder A., Khan M. R. The relationship of cholera to water source and use in rural Bangladesh. Int J Epidemiol. 1981 Mar;10(1):23–25. doi: 10.1093/ije/10.1.23. [DOI] [PubMed] [Google Scholar]
  33. Koopman J. S. Diarrhea and school toilet hygiene in Cali, Colombia. Am J Epidemiol. 1978 May;107(5):412–420. doi: 10.1093/oxfordjournals.aje.a112559. [DOI] [PubMed] [Google Scholar]
  34. Kourany M., Vasquez M. A., Mata L. J. Prevalence of pathogenic enteric bacteria in children of 31 Panamanian communities. Am J Trop Med Hyg. 1971 Jul;20(4):608–615. doi: 10.4269/ajtmh.1971.20.608. [DOI] [PubMed] [Google Scholar]
  35. Levine R. J., Khan M. R., D'Souza S., Nalin D. R. Failure of sanitary wells to protect against cholera and other diarrhoeas in Bangladesh. Lancet. 1976 Jul 10;2(7976):86–89. doi: 10.1016/s0140-6736(76)92299-6. [DOI] [PubMed] [Google Scholar]
  36. Martorell R., Habicht J. P., Yarbrough C., Lechtig A., Klein R. E., Western K. A. Acute morbidity and physical growth in rural Guatemalan children. Am J Dis Child. 1975 Nov;129(11):1296–1301. doi: 10.1001/archpedi.1975.02120480022007. [DOI] [PubMed] [Google Scholar]
  37. Mathur T. N., Kaur J. The epidemiology of amoebiasis in an urban area. Indian J Med Res. 1972 Aug;60(8):1134–1137. [PubMed] [Google Scholar]
  38. McCABE L. J., HAINES T. W. Diarrheal disease control by improved human excreta disposal. Public Health Rep. 1957 Oct;72(10):921–928. [PMC free article] [PubMed] [Google Scholar]
  39. Moore H. A., De la Cruz E., Vargas-Mendez O. Diarrheal disease studies in Costa Rica. IV. The influence of sanitation upon the prevalence of intestinal infection and diarrheal disease. Am J Epidemiol. 1965 Sep;82(2):162–184. doi: 10.1093/oxfordjournals.aje.a120542. [DOI] [PubMed] [Google Scholar]
  40. PETERSEN N. J., HINES V. D. The relation of summertime gastrointestinal illness to the sanitary quality of the water supplies in six Rocky Mountain communities. Am J Hyg. 1960 May;71:314–320. doi: 10.1093/oxfordjournals.aje.a120115. [DOI] [PubMed] [Google Scholar]
  41. Rajasekaran P., Dutt P. R., Pisharoti K. A. Impact of water supply on the incidence of diarrhoea and shigellosis among children in rural communities in Madurai. Indian J Med Res. 1977 Aug;66(2):189–199. [PubMed] [Google Scholar]
  42. Rowland M. G., Cole T. J., Whitehead R. G. A quantitative study into the role of infection in determining nutritional status in Gambian village children. Br J Nutr. 1977 May;37(3):441–450. doi: 10.1079/bjn19770047. [DOI] [PubMed] [Google Scholar]
  43. Rubenstein A., Boyle J., Odoroff C. L., Kunitz S. J. Effect of improved sanitary facilities on infant diarrhea in a Hopi village. Public Health Rep. 1969 Dec;84(12):1093–1097. [PMC free article] [PubMed] [Google Scholar]
  44. SCHLIESSMANN D. J. Diarrhoel disease and the environment. Bull World Health Organ. 1959;21:381–386. [PMC free article] [PubMed] [Google Scholar]
  45. STEWART W. H., McCABE L. J., Jr, HEMPHILL E. C., DeCAPITO T. Diarrheal disease control studies; the relationship of certain environmental factors to the prevalence of Shigella infection. Am J Trop Med Hyg. 1955 Jul;4(4):718–724. [PubMed] [Google Scholar]
  46. Shuval H. I., Tilden R. L., Perry B. H., Grosse R. N. Effect of investments in water supply and sanitation on health status: a threshold-saturation theory. Bull World Health Organ. 1981;59(2):243–248. [PMC free article] [PubMed] [Google Scholar]
  47. Snyder J. D., Merson M. H. The magnitude of the global problem of acute diarrhoeal disease: a review of active surveillance data. Bull World Health Organ. 1982;60(4):605–613. [PMC free article] [PubMed] [Google Scholar]
  48. Sommer A., Woodward W. E. The influence of protected water supplies on the spread of classical-Inaba and El Tor-Ogawa cholera in rural East Bengal. Lancet. 1972 Nov 11;2(7785):985–987. doi: 10.1016/s0140-6736(72)92401-4. [DOI] [PubMed] [Google Scholar]
  49. Spira W. M., Khan M. U., Saeed Y. A., Sattar M. A. Microbiological surveillance of intra-neighbourhood E1 Tor cholera transmission in rural Bangladesh. Bull World Health Organ. 1980;58(5):731–740. [PMC free article] [PubMed] [Google Scholar]
  50. Thacker S. B., Music S. I., Pollard R. A., Berggren G., Boulos C., Nagy T., Brutus M., Pamphile M., Ferdinand R. O., Joseph V. R. Acute water shortage and health problems in Haiti. Lancet. 1980 Mar 1;1(8166):471–473. doi: 10.1016/s0140-6736(80)91009-0. [DOI] [PubMed] [Google Scholar]
  51. Tomkins A. M., Drasar B. S., Bradley A. K., Williamson W. A. Water supply and nutritional status in rural northern Nigeria. Trans R Soc Trop Med Hyg. 1978;72(3):239–243. doi: 10.1016/0035-9203(78)90201-8. [DOI] [PubMed] [Google Scholar]
  52. Trivedi B. K., Gandhi H. S., Shukla N. K. Bacteriological water quality and incidence of water borne diseases in a rural population. Indian J Med Sci. 1971 Nov;25(11):795–801. [PubMed] [Google Scholar]
  53. WATT J., HOLLISTER A. C., Jr, BECK M. D., HEMPHILL E. C. Diarrheal diseases in Fresno County, California. Am J Public Health Nations Health. 1953 Jun;43(6 Pt 1):728–741. doi: 10.2105/ajph.43.6_pt_1.728. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Wolff H. L., van Zijl W. J. Houseflies, the availability of water, and diarrhoeal diseases. Bull World Health Organ. 1969;41(6):952–959. [PMC free article] [PubMed] [Google Scholar]
  55. Wray J. D. Direct nutrition intervention and the control of diarrheal diseases in preschool children. Am J Clin Nutr. 1978 Nov;31(11):2073–2082. doi: 10.1093/ajcn/31.11.2073. [DOI] [PubMed] [Google Scholar]
  56. ZAHEER M., PRASAD B. G., GOVIL K. K., BHADURYT A note on urban water supply in Uttar Pradesh. J Indian Med Assoc. 1962 Feb 16;38:177–182. [PubMed] [Google Scholar]
  57. de Zoysa I., Feachem R. G. Interventions for the control of diarrhoeal diseases among young children: chemoprophylaxis. Bull World Health Organ. 1985;63(2):295–315. [PMC free article] [PubMed] [Google Scholar]
  58. de Zoysa I., Feachem R. G. Interventions for the control of diarrhoeal diseases among young children: rotavirus and cholera immunization. Bull World Health Organ. 1985;63(3):569–583. [PMC free article] [PubMed] [Google Scholar]
  59. van Zijl W. J. Studies on diarrhoeal diseases in seven countries by the WHO diarrhoeal diseases advisory team. Bull World Health Organ. 1966;35(2):249–261. [PMC free article] [PubMed] [Google Scholar]

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