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. 1985;63(2):273–277.

Antigenic and amino acid sequence analyses of influenza viruses of the H1N1 subtype isolated between 1982 and 1984

R S Daniels, A R Douglas, J J Skehel, D C Wiley
PMCID: PMC2536405  PMID: 2410157

Abstract

Since the reintroduction of influenza viruses of the H1N1 subtype into the human population in 1977, antigenically distinguishable viruses have been isolated each year from outbreaks of respiratory disease in young people. In this paper the antigenic properties of viruses representative of isolates made in 1982, 1983, and 1984 are compared, and the amino acid sequences of their haemagglutinins are presented. The results provide a complete description of the 1982 and 1983 H1N1 influenza virus haemagglutinins and allow correlation of specific amino acid sequence differences with antigenic differences.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Caton A. J., Brownlee G. G., Yewdell J. W., Gerhard W. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell. 1982 Dec;31(2 Pt 1):417–427. doi: 10.1016/0092-8674(82)90135-0. [DOI] [PubMed] [Google Scholar]
  2. Kendal A. P., Noble G. R., Skehel J. J., Dowdle W. R. Antigenic similarity of influenza A (H1N1) viruses from epidemics in 1977--1978 to "Scandinavian" strains isolated in epidemics of 1950--1951. Virology. 1978 Sep;89(2):632–636. doi: 10.1016/0042-6822(78)90207-6. [DOI] [PubMed] [Google Scholar]
  3. Nakajima K., Desselberger U., Palese P. Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950. Nature. 1978 Jul 27;274(5669):334–339. doi: 10.1038/274334a0. [DOI] [PubMed] [Google Scholar]
  4. Nakajima S., Nakajima K., Kendal A. P. Identification of the binding sites to monoclonal antibodies on A/USSR/90/77 (H1N1) hemagglutinin and their involvement in antigenic drift in H1N1 influenza viruses. Virology. 1983 Nov;131(1):116–127. doi: 10.1016/0042-6822(83)90538-x. [DOI] [PubMed] [Google Scholar]
  5. Scholtissek C., von Hoyningen V., Rott R. Genetic relatedness between the new 1977 epidemic strains (H1N1) of influenza and human influenza strains isolated between 1947 and 1957 (H1N1). Virology. 1978 Sep;89(2):613–617. doi: 10.1016/0042-6822(78)90203-9. [DOI] [PubMed] [Google Scholar]
  6. Skehel J. J., Daniels R. S., Douglas A. R., Wiley D. C. Antigenic and amino acid sequence variations in the haemagglutinins of type A influenza viruses recently isolated from human subjects. Bull World Health Organ. 1983;61(4):671–676. [PMC free article] [PubMed] [Google Scholar]
  7. Wiley D. C., Wilson I. A., Skehel J. J. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature. 1981 Jan 29;289(5796):373–378. doi: 10.1038/289373a0. [DOI] [PubMed] [Google Scholar]
  8. Wilson I. A., Skehel J. J., Wiley D. C. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature. 1981 Jan 29;289(5796):366–373. doi: 10.1038/289366a0. [DOI] [PubMed] [Google Scholar]
  9. Winter G., Fields S., Brownlee G. G. Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype. Nature. 1981 Jul 2;292(5818):72–75. doi: 10.1038/292072a0. [DOI] [PubMed] [Google Scholar]

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