Abstract
On a global scale, 480 million people were recently estimated to be infected with Entamoeba histolytica and some 48 million people suffer from invasive amoebiasis. The latter, in the intestinal and extra-intestinal forms, accounts for 40 000 to 110 000 deaths annually. In view of this considerable mortality and morbidity, more research is urgently needed so that more effective control strategies may be introduced.
This Update article reviews the magnitude of the problem, clinical and laboratory diagnosis, present treatment and prevention measures, possible control strategies, and research priorities.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Guerrant R. L., Brush J., Ravdin J. I., Sullivan J. A., Mandell G. L. Interaction between Entamoeba histolytica and human polymorphonuclear neutrophils. J Infect Dis. 1981 Jan;143(1):83–93. doi: 10.1093/infdis/143.1.83. [DOI] [PubMed] [Google Scholar]
- Martínez-Palomo A., Martínez-Báez M. Selective primary health care: strategies for control of disease in the developing world. X. Amebiasis. Rev Infect Dis. 1983 Nov-Dec;5(6):1093–1102. doi: 10.1093/clinids/5.6.1093. [DOI] [PubMed] [Google Scholar]
- Pillai S., Mohimen A. A solid-phase sandwich radioimmunoassay for Entamoeba histolytica proteins and the detection of circulating antigens in amoebiasis. Gastroenterology. 1982 Dec;83(6):1210–1216. [PubMed] [Google Scholar]
- Ravdin J. I., Guerrant R. L. A review of the parasite cellular mechanisms involved in the pathogenesis of amebiasis. Rev Infect Dis. 1982 Nov-Dec;4(6):1185–1207. doi: 10.1093/clinids/4.6.1185. [DOI] [PubMed] [Google Scholar]
- Sargeaunt P. G., Jackson T. F., Simjee A. Biochemical homogeneity of Entamoeba histolytica isolates, especially those from liver abscess. Lancet. 1982 Jun 19;1(8286):1386–1388. doi: 10.1016/s0140-6736(82)92502-8. [DOI] [PubMed] [Google Scholar]
- Susskind B. M., Warren L. G., Reeves R. E. A pathway for the interconversion of hexose and pentose in the parasitic amoeba Entamoeba histolytica. Biochem J. 1982 Apr 15;204(1):191–196. doi: 10.1042/bj2040191. [DOI] [PMC free article] [PubMed] [Google Scholar]