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letter
. 1978 Feb;70(2):87–88.

The Placenta: A Diagnostic Tool in Sickle Cell Disorders

Randall D Bloomfield, Jorge R Suarez, Ansenio C Malangit
PMCID: PMC2537050  PMID: 702553

Abstract

Examination of the placenta for the presence of sickling is an accurate, simple, inexpensive, and readily available technique for determining the presence of sickle cell disorders. There were 24 placental specimens out of 904 which showed evidence of sickling. The importance of this confirming procedure can be seen in the uncovering of two cases of false negative reports from conventional testing.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Motulsky A. G. Frequency of sickling disorders in U.S. blacks. N Engl J Med. 1973 Jan 4;288(1):31–33. doi: 10.1056/NEJM197301042880108. [DOI] [PubMed] [Google Scholar]
  2. Murayama M. Molecular mechanism of red cell "sickling". Science. 1966 Jul 8;153(3732):145–149. doi: 10.1126/science.153.3732.145. [DOI] [PubMed] [Google Scholar]
  3. Neel J. V. The Inheritance of Sickle Cell Anemia. Science. 1949 Jul 15;110(2846):64–66. doi: 10.1126/science.110.2846.64. [DOI] [PubMed] [Google Scholar]
  4. Schneider R. G., Alperin J. B., Lehmann H. Sickling tests. Pitfalls in performance and interpretation. JAMA. 1967 Oct 30;202(5):419–421. doi: 10.1001/jama.202.5.419. [DOI] [PubMed] [Google Scholar]
  5. White J. G. Ultrastructural features of erythrocyte and hemoglobin sickling. Arch Intern Med. 1974 Apr;133(4):545–562. [PubMed] [Google Scholar]

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