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. 1988 Aug;62(8):2782–2789. doi: 10.1128/jvi.62.8.2782-2789.1988

Antigenic sites on foot-and-mouth disease virus type A10.

A A Thomas 1, R J Woortmeijer 1, W Puijk 1, S J Barteling 1
PMCID: PMC253712  PMID: 2455819

Abstract

A set of monoclonal antibodies was used to isolate nonneutralizable foot-and-mouth disease virus variants, and the RNAs of the variants were sequenced. Cross-neutralization studies and mapping of the amino acid changes indicated two major antigenic sites. The first site was trypsin sensitive and included the VP1 140 to 160 sequence. The second site was trypsin insensitive and included mainly VP3 residues. Two minor sites were located near VP1 169 and on the C terminus of VP1. Comparison with poliovirus type 1 and human rhinovirus 14 showed a similarity in the immunogenicity of comparable sites on the viruses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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