Abstract
Malignant salivary gland tumors are rare. They represent less than one percent of all head and neck tumors. Approximately three fourths of all salivary gland tumors occur in the major salivary glands.
Traditionally, the treatment of choice for these tumors is surgery. The majority of these tumors reoccur after curative surgical procedures. Local recurrence rate following surgery varies with the histology, grade, and extent of the disease.
In spite of high local recurrence rate following curative surgical treatment of these tumors, radiotherapy has seldom been used as an adjuvant to surgery. The value of elective postoperative radiation therapy for subclinical microscopic disease was not recognized. Review of the literature supports the improved local control rate with the use of immediate postoperative radiotherapy. Radiation therapy proved to be effective as an adjuvant to surgery. A local control rate of better than 40 percent can be achieved by radiation therapy as a sole modality in inoperable and locally advanced cases. Radiation therapy provides an excellent palliation for locally advanced tumors or symptomatic metastases.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ALANIZ F., FLETCHER G. H. PLACE AND TECHNICS OF RADIATION THERAPY IN THE MANAGEMENT OF MALIGNANT TUMORS OF THE MAJOR SALIVARY GLANDS. Radiology. 1965 Mar;84:412–419. doi: 10.1148/84.3.412. [DOI] [PubMed] [Google Scholar]
- BEAHRS O. H., WOOLNER L. B., CARVETH S. W., DEVINE K. D. Surgical management of parotid lesions. Review of seven hundred sixty cases. Arch Surg. 1960 Jun;80:890–904. doi: 10.1001/archsurg.1960.01290230008002. [DOI] [PubMed] [Google Scholar]
- Bagshaw M. A., Thompson R. W. Elective irradiation of the neck in patients with primary carcinoma of the head and neck. JAMA. 1971 Jul 26;217(4):456–458. [PubMed] [Google Scholar]
- Dunn E. J., Kent T., Hines J., Cohn I., Jr Parotid neoplasms: a report of 250 cases and review of the literature. Ann Surg. 1976 Oct;184(4):500–506. doi: 10.1097/00000658-197610000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Elkon D., Colman M., Hendrickson F. R. Radiation therapy in the treatment of malignant salivary gland tumors. Cancer. 1978 Feb;41(2):502–506. doi: 10.1002/1097-0142(197802)41:2<502::aid-cncr2820410217>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
- FOOTE F. W., Jr, FRAZELL E. L. Tumors of the major salivary glands. Cancer. 1953 Nov;6(6):1065–1133. doi: 10.1002/1097-0142(195311)6:6<1065::aid-cncr2820060602>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
- Fayos J. V. The role of radiotherapy in salivary gland neoplasms. Otolaryngol Clin North Am. 1977 Jun;10(2):431–435. [PubMed] [Google Scholar]
- Fletcher G. H. Elective irradiation of subclinical disease in cancers of the head and neck. Cancer. 1972 Jun;29(6):1450–1454. doi: 10.1002/1097-0142(197206)29:6<1450::aid-cncr2820290605>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
- Fu K. K., Leibel S. A., Levine M. L., Friedlander L. M., Boles R., Phillips T. L. Carcinoma of the major and minor salivary glands: analysis of treatment results and sites and causes of failures. Cancer. 1977 Dec;40(6):2882–2890. [PubMed] [Google Scholar]
- Guillamondegui O. M., Byers R. M., Luna M. A., Chiminazzo H., Jr, Jesse R. H., Fletcher G. H. Aggressive surgery in treatment for parotid cancer: the role of adjunctive postoperative radiotherapy. Am J Roentgenol Radium Ther Nucl Med. 1975 Jan;123(1):49–54. doi: 10.2214/ajr.123.1.49. [DOI] [PubMed] [Google Scholar]
- Hollander L., Cunningham M. P. Management of cancer of the parotid gland. Surg Clin North Am. 1973 Feb;53(1):113–119. doi: 10.1016/s0039-6109(16)39937-6. [DOI] [PubMed] [Google Scholar]
- Kagan A. R., Nussbaum H., Handler S., Shapiro R., Gilbert H. A., Jacobs M., Miles J. W., Chan P. Y., Calcaterra T. Recurrences from malignant parotid salivary gland tumors. Cancer. 1976 Jun;37(6):2600–2604. doi: 10.1002/1097-0142(197606)37:6<2600::aid-cncr2820370606>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
- King J. J., Fletcher G. H. Malignant tumors of the major salivary glands. Radiology. 1971 Aug;100(2):381–384. doi: 10.1148/100.2.381. [DOI] [PubMed] [Google Scholar]
- Patey D. H., Thackray A. C., Keeling D. H. Malignant disease of the parotid. Br J Cancer. 1965 Dec;19(4):712–737. doi: 10.1038/bjc.1965.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perzik S. L., Fisher B. The place of neck dissection in the management of parotid tumors. Am J Surg. 1970 Sep;120(3):355–358. [PubMed] [Google Scholar]
- Rafla S. Malignant parotid tumors: natural history and treatment. Cancer. 1977 Jul;40(1):136–144. doi: 10.1002/1097-0142(197707)40:1<136::aid-cncr2820400123>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
- Richardson G. S., Dickason W. L., Gaisford J. C., Hanna D. C. Tumors of salivary glands. An analysis of 752 cases. Plast Reconstr Surg. 1975 Feb;55(2):131–138. doi: 10.1097/00006534-197502000-00001. [DOI] [PubMed] [Google Scholar]
- Rosenfeld L., Sessions D. G., McSwain B., Graves H., Jr Malignant tumors of salivary gland origin: 37-year review of 184 cases. Ann Surg. 1966 May;163(5):726–735. doi: 10.1097/00000658-196605000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rossman K. J. The role of radiation therapy in the treatment of parotid carcinomas. Am J Roentgenol Radium Ther Nucl Med. 1975 Mar;123(3):492–499. doi: 10.2214/ajr.123.3.492. [DOI] [PubMed] [Google Scholar]
- Spiro R. H., Huvos A. G., Strong E. W. Cancer of the parotid gland. A clinicopathologic study of 288 primary cases. Am J Surg. 1975 Oct;130(4):452–459. doi: 10.1016/0002-9610(75)90483-3. [DOI] [PubMed] [Google Scholar]
- Stewart J. G., Jackson A. W., Chew M. K. The role of radiotherapy in the management of malignant tumors of the salivary glands. Am J Roentgenol Radium Ther Nucl Med. 1968 Jan;102(1):100–108. doi: 10.2214/ajr.102.1.100. [DOI] [PubMed] [Google Scholar]
