Abstract
A field trial of dried BCG vaccine prepared with sodium glutamate as adjuvant was carried out by the WHO/UNICEF Tuberculosis Survey Team for West Africa in Ilorin, Nigeria, in April 1956. This trial—the first of a series of studies being undertaken jointly by the WHO Tuberculosis Research Office and the Japan Anti-Tuberculosis Association—was designed to test the heat-stability of the new dried vaccine.
The allergenic potency six months after vaccination of two different lots of glutamate vaccine stored under various temperature conditions was compared with that of a batch of fresh liquid vaccine stored at 2-4° C. The results showed both lots of dried vaccine to be remarkably heat-stable: even after 30 days' exposure to tropical temperatures, no marked loss of allergenic potency was observed.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BIRKHAUG K. The effect of time and temperature on antigenic potency of BCG vaccine. II. Storage at 20 degrees and 37.5 degrees C. Am Rev Tuberc. 1954 Nov;70(5):873–880. doi: 10.1164/art.1954.70.5.873. [DOI] [PubMed] [Google Scholar]
- CHO C., OBAYASHI Y. Effect of adjuvant on preservability of dried BCG vaccine at 37 degrees C. Bull World Health Organ. 1956;14(4):657–669. [PMC free article] [PubMed] [Google Scholar]
- ENGBAEK H. C., FRIIS T. Immunizing effect of BCG vaccine treated and stored in various ways. Acta Pathol Microbiol Scand. 1953;32(4):522–528. doi: 10.1111/j.1699-0463.1953.tb00282.x. [DOI] [PubMed] [Google Scholar]