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. 1987 Feb;61(2):383–387. doi: 10.1128/jvi.61.2.383-387.1987

Abrogation of resistance to severe mousepox in C57BL/6 mice infected with LP-BM5 murine leukemia viruses.

R M Buller, R A Yetter, T N Fredrickson, H C Morse 3rd
PMCID: PMC253960  PMID: 3027368

Abstract

Strain C57BL/6 (B6) mice infected with LP-BM5 murine leukemia virus (MuLV) develop a disease which combines abnormal lymphoproliferation with profound immunosuppression and has many features in common with human acquired immunodeficiency syndrome induced by HTLV-III/LAV retroviruses. To determine whether this LP-BM5 MuLV infection would affect the innate resistance of B6 mice to a naturally occurring, highly virulent murine pathogen, mice were exposed to ectromelia virus at various times after treatment with LP-BM5 viruses. At week 4 after infection with LP-BM5, mice challenged with ectromelia virus were unable to generate a humoral immune response to this virus, and between weeks 8 and 10 after infection, challenged mice lost the ability to generate an ectromelia virus-specific cytotoxic-T-cell response. Loss of the cellular immune responses to ectromelia virus was associated with an increased susceptibility to the lethal effects of the virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen A. M., Clarke G. L., Ganaway J. R., Lock A., Werner R. M. Pathology and diagnosis of mousepox. Lab Anim Sci. 1981 Oct;31(5 Pt 2):599–608. [PubMed] [Google Scholar]
  2. Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. 3. Regression infectious foci. J Exp Med. 1971 May 1;133(5):1090–1104. doi: 10.1084/jem.133.5.1090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum. J Exp Med. 1970 Nov;132(5):1035–1054. doi: 10.1084/jem.132.5.1035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells. J Exp Med. 1971 May 1;133(5):1074–1089. doi: 10.1084/jem.133.5.1074. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Blanden R. V., Mims C. A. Macrophage activation in mice infected with ectromelia or lymphocytic choriomeningitis viruses. Aust J Exp Biol Med Sci. 1973 Jun;51(3):393–398. doi: 10.1038/icb.1973.35. [DOI] [PubMed] [Google Scholar]
  6. Buller R. M., Wallace G. D. Reexamination of the efficacy of vaccination against mousepox. Lab Anim Sci. 1985 Oct;35(5):473–476. [PubMed] [Google Scholar]
  7. Gardner M. B., Henderson B. E., Officer J. E., Rongey R. W., Parker J. C., Oliver C., Estes J. D., Huebner R. J. A spontaneous lower motor neuron disease apparently caused by indigenous type-C RNA virus in wild mice. J Natl Cancer Inst. 1973 Oct;51(4):1243–1254. doi: 10.1093/jnci/51.4.1243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Haas M., Meshorer A. Reticulum cell neoplasms induced in C57BL/6 mice by cultured virus grown in stromal hematopoietic cell lines. J Natl Cancer Inst. 1979 Aug;63(2):427–439. [PubMed] [Google Scholar]
  9. Hoffman P. M., Davidson W. F., Ruscetti S. K., Chused T. M., Morse H. C., 3rd Wild mouse ecotropic murine leukemia virus infection of inbred mice: dual-tropic virus expression precedes the onset of paralysis and lymphoma. J Virol. 1981 Aug;39(2):597–602. doi: 10.1128/jvi.39.2.597-602.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. JOKLIK W. K. The purification fo four strains of poxvirus. Virology. 1962 Sep;18:9–18. doi: 10.1016/0042-6822(62)90172-1. [DOI] [PubMed] [Google Scholar]
  11. Kawashima K., Ikeda H., Hartley J. W., Stockert E., Rowe W. P., Old L. J. Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4680–4684. doi: 10.1073/pnas.73.12.4680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LATARJET R., DUPLAN J. F. Experiment and discussion on leukaemogenesis by cell-free extracts of radiation-induced leukaemia in mice. Int J Radiat Biol Relat Stud Phys Chem Med. 1962 Aug;5:339–344. doi: 10.1080/09553006214550911. [DOI] [PubMed] [Google Scholar]
  13. Lane H. C., Masur H., Edgar L. C., Whalen G., Rook A. H., Fauci A. S. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1983 Aug 25;309(8):453–458. doi: 10.1056/NEJM198308253090803. [DOI] [PubMed] [Google Scholar]
  14. Metroka C. E., Cunningham-Rundles S., Pollack M. S., Sonnabend J. A., Davis J. M., Gordon B., Fernandez R. D., Mouradian J. Generalized lymphadenopathy in homosexual men. Ann Intern Med. 1983 Nov;99(5):585–591. doi: 10.7326/0003-4819-99-5-585. [DOI] [PubMed] [Google Scholar]
  15. Morse H. C., 3rd, Yetter R. A., Stimpfling J. H., Pitts O. M., Fredrickson T. N., Hartley J. W. Greying with age in mice: relation to expression of murine leukemia viruses. Cell. 1985 Jun;41(2):439–448. doi: 10.1016/s0092-8674(85)80017-9. [DOI] [PubMed] [Google Scholar]
  16. Mosier D. E., Yetter R. A., Morse H. C., 3rd Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J Exp Med. 1985 Apr 1;161(4):766–784. doi: 10.1084/jem.161.4.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. O'Neill H. C., Blanden R. V. Mechanisms determining innate resistance to ectromelia virus infection in C57BL mice. Infect Immun. 1983 Sep;41(3):1391–1394. doi: 10.1128/iai.41.3.1391-1394.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. O'Neill H. C., Blanden R. V., O'Neill T. J. H-2-linked control of resistance to ectromelia virus infection in B10 congenic mice. Immunogenetics. 1983;18(3):255–265. doi: 10.1007/BF00952964. [DOI] [PubMed] [Google Scholar]
  19. Pattengale P. K., Taylor C. R., Twomey P., Hill S., Jonasson J., Beardsley T., Haas M. Immunopathology of B-cell lymphomas induced in C57BL/6 mice by dualtropic murine leukemia virus (MuLV). Am J Pathol. 1982 Jun;107(3):362–377. [PMC free article] [PubMed] [Google Scholar]
  20. ROBERTS J. A. GROWTH OF VIRULENT AND ATTENUATED ECTROMELIA VIRUS IN CULTURED MACROPHAGES FROM NORMAL AND ECTROMELIAIMMUNE MICE. J Immunol. 1964 Jun;92:837–842. [PubMed] [Google Scholar]
  21. Rowe W. P. Deformed whiskers in mice infected with certain exogenous murine leukemia viruses. Science. 1983 Aug 5;221(4610):562–564. doi: 10.1126/science.6306769. [DOI] [PubMed] [Google Scholar]
  22. Rowe W. P., Pugh W. E., Hartley J. W. Plaque assay techniques for murine leukemia viruses. Virology. 1970 Dec;42(4):1136–1139. doi: 10.1016/0042-6822(70)90362-4. [DOI] [PubMed] [Google Scholar]
  23. Wallace G. D., Buller R. M. Kinetics of ectromelia virus (mousepox) transmission and clinical response in C57BL/6j, BALB/cByj and AKR/J inbred mice. Lab Anim Sci. 1985 Feb;35(1):41–46. [PubMed] [Google Scholar]
  24. Wallace G. D., Buller R. M., Morse H. C., 3rd Genetic determinants of resistance to ectromelia (mousepox) virus-induced mortality. J Virol. 1985 Sep;55(3):890–891. doi: 10.1128/jvi.55.3.890-891.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]

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